An insulin-IAPP hybrid peptide is an endogenous antigen for CD4 …
We have now confirmed by testing NOD.IAPP−/− islet cells that expression of IAPP is critical for generation of the BDC-6.9 antigen. We have demonstrated that the precise epitope for the HIP …
Novel autoantigens in type 1 diabetes - PMC
Then mini-mRNAs encoding these epitope sequences can be transfected into autologous antigen presenting cells (APCs), or the synthesized peptides can be loaded into autologous APCs and …
A human antibody against pathologic IAPP aggregates protects
2023年10月9日 · Here, we describe a human monoclonal antibody selectively targeting IAPP oligomers and neutralizing IAPP aggregate toxicity by preventing membrane disruption and …
A Novel Tolerogenic Antibody Targeting Disulfide-Modified …
2022年8月11日 · Increasing evidence suggested that the islet amyloid polypeptide (IAPP) is an essential autoantigen in the pathogenesis of type 1 diabetes (T1D) in humans and non-obese …
Genetic Associations of Type 2 Diabetes with Islet Amyloid ... - PLOS
2013年6月11日 · In this report, we used a tag single nucleotide polymorphism (SNP) approach to select genetic variants of candidate genes (APCS, CPE, IAPP, IDE, PCSK1 and PCSK2) …
Recognition of Multiple Hybrid Insulin Peptides by a Single Highly ...
2021年8月29日 · Autoantigen expression in artificial APCs was driven by transgenes encoding human invariant chain (Ii 1-80)-β-cell autoantigen-BDC2.5 mimotope (HHPIWARMDA) …
The MHC-II peptidome of pancreatic islets identifies key ... - Nature
2020年3月9日 · Here, we examined the immunopeptidome of the pancreatic islets in non-obese diabetic mice, which spontaneously develop autoimmune diabetes based on the I-A g7 variant …
Revisiting the Antigen-Presenting Function of β Cells in T1D ...
2021年7月14日 · The islet resident antigen-presenting cells (APCs) including dendritic cells and macrophages uptake and process the β cell-derived antigens to prime the autoreactive …
CD4+ T cells reactive to a hybrid peptide from insulin …
2024年8月29日 · A hybrid-insulin peptide (HIP) derived from insulin C-chain and ChgA (InsC-ChgA) was recently identified as the BDC-2.5 antigen. 6 In addition, CD4 + T cells specific for …
APCS Gene - GeneCards | SAMP Protein | SAMP Antibody
2024年12月24日 · APCS (Amyloid P Component, Serum) is a Protein Coding gene. Diseases associated with APCS include Candidiasis and Amyloidosis, Hereditary Systemic 2. Among its …