2024年4月1日 · We show that IAPP tagged with green fluorescent protein (GFP) localises to mitochondria not only in muscle cells but also when expressed in the intestine, in line with previous observations in mouse and human pancreatic β-cells.

2016年9月19日 · In type 2 diabetes, the formation of islet amyloid consisting of islet amyloid polypeptide (IAPP) is associated with reduction in β-cell mass and contributes to the failure of islet cell...

2018年9月1日 · We summarize information on expression of the IAPP gene, the regulation of the hormone by post-translational modifications, the structural properties of the peptide in various states, the kinetics of misfolding to amyloid fibrils, and the interactions of the peptide with insulin, membranes, glycosaminoglycans, and nanoparticles.

Human islet amyloid polypeptide (IAPP or amylin) is a 37-residue hormone found as fibrillar deposits in pancreatic extracts of nearly all type II diabetics. Although the cellular toxicity of IAPP has been established, the structure of the fibrillar form found in these deposits is unknown.

2021年10月15日 · IAPP resides a high propensity to form amyloid and in the commonly used ThT assay that allows monitoring of the amyloid fibril formation; the peptide usually displays a short lag phase, while the Aβ peptide lag phase is usually significantly longer.

2012年12月21日 · Islet amyloid polypeptide (IAPP) is a major component of pancreatic amyloid deposits associated with type 2 diabetes. Polyphenols contained in plant foods have been found to inhibit amyloid fibril formation of proteins and/or peptides. However, the inhibition mechanism is not clear for a variety of …

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2012年4月3日 · EGCG is the most abundant biologically active compound in green tea and inhibits amyloid formation in vitro by a range of natively unfolded polypeptides including islet amyloid polypeptide, (IAPP, also known as Amylin), Aβ, α-synuclein, the AIDs enhancer factor SEVI, and the surface protein from Plasmodium falcipran merozite.