Islet amyloid polypeptide tagged with green fluorescent protein ...
2024年4月1日 · We show that IAPP tagged with green fluorescent protein (GFP) localises to mitochondria not only in muscle cells but also when expressed in the intestine, in line with …
β-Hairpin of Islet Amyloid Polypeptide Bound to an Aggregation ...
2016年9月19日 · In type 2 diabetes, the formation of islet amyloid consisting of islet amyloid polypeptide (IAPP) is associated with reduction in β-cell mass and contributes to the failure of …
IAPP in type II diabetes: Basic research on structure, molecular ...
2018年9月1日 · We summarize information on expression of the IAPP gene, the regulation of the hormone by post-translational modifications, the structural properties of the peptide in various …
Atomic structure of the cross-β spine of islet amyloid polypeptide ...
Human islet amyloid polypeptide (IAPP or amylin) is a 37-residue hormone found as fibrillar deposits in pancreatic extracts of nearly all type II diabetics. Although the cellular toxicity of …
The Amyloid Forming Peptides Islet Amyloid Polypeptide and …
2021年10月15日 · IAPP resides a high propensity to form amyloid and in the commonly used ThT assay that allows monitoring of the amyloid fibril formation; the peptide usually displays a short …
Inhibitory mechanism of pancreatic amyloid fibril formation: …
2012年12月21日 · Islet amyloid polypeptide (IAPP) is a major component of pancreatic amyloid deposits associated with type 2 diabetes. Polyphenols contained in plant foods have been …
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Analysis of the Inhibition and Remodeling of Islet Amyloid …
2012年4月3日 · EGCG is the most abundant biologically active compound in green tea and inhibits amyloid formation in vitro by a range of natively unfolded polypeptides including islet …