NS1: A Key Protein in the “Game” Between Influenza A Virus and …
Here, we focus on the NS1 protein and illustrate its effects on IAV virulence and pathogenicity, as well as the molecular mechanisms by which the NS1 protein antagonizes host innate immunity …
甲型流感病毒非结构蛋白NS1功能研究进展 - Fudan University
IAV的NS1抵抗宿主抗病毒应答效应主要表现在抑制IFN的合成及抑制IFN诱导表达的抗病毒基因ISG(interferon-stimulated gene)激活两方面。这两种功能主要由NS1的C端ED区执行，由于ED …
The applications of live attenuated influenza a virus with modified NS1 …
2025年3月11日 · Published research has demonstrated that the NS1 proteins from H3N2 and H2N2 viruses can effectively bind to CPSF30, thereby inhibiting pre-mRNA processing of …
Research progress on the nonstructural protein 1 (NS1) of …
The non-structural protein 1 (NS1) is encoded by segment 8 of IAV genome and is expressed in high levels in host cells upon IAV infection. It is the determinant of virulence and has multiple …
Atractylenolide-Ⅲ binds non-structural protein-1 to suppress …
2 天之前 · Surface plasmon resonance (SPR) analysis was utilized to determine the binding affinity of ACT-Ⅲ to NS1. The anti-IAV activity of ACT-Ⅲ was further tested in vitro using IAV …
Molecular mechanism of influenza A NS1-mediated TRIM25 ... - Nature
2018年5月8日 · TRIM25 activity is targeted by influenza A virus non-structural protein 1 (NS1) to suppress IFN production and prevent an efficient host immune response. Here we present …
Restriction of influenza A virus replication by host DCAF7-CRL4B axis
4 天之前 · We observed that only IAV NS1 protein, but not other viral proteins, decreased the mRNA and protein levels of DCAF7 (Fig. 10I and J). Consistently, Chen et al. infected …
Evolutionary rewiring of the dynamic network underpinning …
2025年2月20日 · Nonstructural protein 1 (NS1) is a major virulence factor of the influenza A virus (IAV) that activates host PI3K by binding to its p85β subunit. Here, we present a deep analysis …
Full article: Eukaryotic RNA binding protein hnRNPH1 suppresses ...
2025年3月17日 · Through conducting experiments to identify NS1-interacting proteins and initial mechanistic investigations, we have discovered that the host protein hnRNPH1 played a role …
NS1 protein as a novel anti-influenza target: Map-and-mutate …
2022年1月2日 · The NS1 protein of influenza A virus (IAV) is a pleiotropic virulence factor that acts as a major innate immune antagonist (namely, type I interferon(IFN)-mediated antiviral …