ICAM-1 is a transmembrane protein possessing an amino-terminus extracellular domain, a single transmembrane domain, and a carboxy-terminus cytoplasmic domain. The structure of ICAM-1 is characterized by heavy glycosylation, and the protein’s extracellular domain is composed of multiple loops created by disulfide bridges within the

ICAM-1（intercellular cell adhesion molecule-1 即细胞间黏附分子-1），又叫做CD54，属于黏附分子中免疫球蛋白超家族（IGSF）中的成员，是介导黏附反应重要的一个黏附分子。 ICAM-1 在静息的血管内皮细胞（VEC）上呈低水平表达，通过与血管内皮细胞表面上的特异性受体结合而发挥其生物学活性。 作为白血球和内皮细胞跨膜的蛋白质，ICAM1在稳定细胞间相互作用和促进白血球和内皮细胞的迁移起到重要作用。 ICAM-1 的受体有LFA-1 (lymphocyte function associated …

2024年12月25日 · ICAM1 (Intercellular Adhesion Molecule 1) is a Protein Coding gene. Diseases associated with ICAM1 include Malaria and Cerebral Malaria. Among its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling and Cytokine Signaling in Immune system.

ICAM-1（Intercellular Cell Adhesion Molecule-1），又叫CD54，中文名为细胞间黏附分子-1，主要功能是介导细胞间的黏附反应。 粘附分子是细胞功能、组织完整性和稳态的关键调节因子，不仅介导细胞间的相互作用，而且通过与细

ICAM-1 is a cell surface glycoprotein and an adhesion receptor that is best known for regulating leukocyte recruitment from circulation to sites of inflammation. However, in addition to vascular endothelial cells, ICAM-1 expression is also robustly induced on epithelial and immune cells in response to inflammatory stimulation.

2024年11月12日 · icam-1（细胞间黏附分子-1）和mcp-1（单核细胞趋化蛋白-1）是两种关键的炎症反应因子，参与免疫细胞的迁移、炎症过程以及组织修复。icam-1主要介导白细胞与内皮细胞的粘附，而mcp-1则能吸引单核细胞向炎症部位聚集，...

2023年8月1日 · Intercellular adhesion molecule 1 (ICAM-1), as well as vascular cell adhesion molecule 1 (VCAM-1), are cell adhesion molecules (CAM) of the immunoglobin family with primary roles in regulating the strong adherence of leukocytes to endothelial muscles in various acute or chronic inflammation diseases [1].

ICAM-1（Intercellular Cell Adhesion Molecule-1），又叫CD54，中文名为细胞间黏附分子-1，主要功能是介导细胞间的黏附反应。 粘附分子是细胞功能、组织完整性和稳态的关键调节因子，不仅介导细胞间的相互作用，而且通过与细胞骨架和各种衔接蛋白的结合，触发细胞内信号传导，以响应特定和局部的提示，如炎症刺激后上皮细胞和免疫细胞中的ICAM-1表达增加。 ICAM-1是许多细胞功能的主要调节因子。 ICAM-1启动子包含多种转录因子的结合位点，如AP-1、SP、NF-κB …

2024年9月11日 · icam1是细胞粘附分子1，又称为cd54，是一种细胞表面糖蛋白，icam-1作为一个生物传感器，通过其胞质结构域与细胞外结构域结合后与肌动蛋白细胞骨架结合来转导由外至内的信号。

2024年11月1日 · In this review, we thoroughly examine recent advancements in understanding the role of ICAM-1 in tumor development, its relevance in predicting therapeutic efficacy and prognosis, as well as the progress in clinical translational research on anti-ICAM-1-based therapies, encompassing including monoclonal antibodies, immunotherapy, antibody-drug c...