Intercellular adhesion molecule 2 (ICAM2), also known as CD102 (Cluster of Differentiation 102), is a human gene, and the protein resulting from it.

所有 ICAM 蛋白都是 I 型跨膜糖蛋白，包含 2-9 个免疫球蛋白样 C2 型结构域，并与白细胞粘附 LFA-1 蛋白结合。 这种蛋白质可能通过阻断 LFA-1 依赖性细胞粘附在淋巴细胞再循环中发挥作用。 它介导对抗原特异性免疫反应很重要的粘附相互作用、NK 细胞介导的清除、淋巴细胞再循环，以及对免疫反应和监视很重要的其他细胞相互作用。 已发现该基因的几种转录变体编码相同的蛋白质。 [RefSeq 提供，2008 年 7 月] The protein encoded by this gene is a member of the …

2024年12月25日 · ICAM2 (Intercellular Adhesion Molecule 2) is a Protein Coding gene. Diseases associated with ICAM2 include Colon Carcinoma In Situ and Intestine Carcinoma In Situ. Among its related pathways are Innate Immune System and CLEC7A (Dectin-1) signaling. Gene Ontology (GO) annotations related to this gene include integrin binding.

Intercellular adhesion molecule 2 as a novel prospective tumor suppressor induced by ERG promotes ubiquitination-mediated radixin degradation to inhibit gastric cancer tumorigenicity and metastasis.

2005年9月1日 · Intercellular adhesion molecule 2 (ICAM-2) is a member of the immunoglobulin (Ig) superfamily, constitutively expressed at the endothelial junctions. 3 Its structure includes 2 extracellular Ig domains, a transmembrane region, and a short intracellular tail. 4 ICAM-2, originally identified as a ligand for leukocyte integrin lymphocyte function–a...

Endothelial intercellular cell adhesion molecule (ICAM)-1 and ICAM-2, in conjunction with ICAM-1 on pericytes, critically contribute to each step. In addition, epithelial ICAM-1 is involved in neutrophil migration to peri-epithelial sites.

2011年1月1日 · Chemokine (C-X-C motif) ligand 17 (CXCL17) and intercellular adhesion molecule 2 (ICAM2) were involved in immune surveillance during tumor development—their expression levels were up-regulated exclusively in IPMA and disappeared from IPMC.

1998年5月8日 · We have previously shown that the endothelial-specific in vivo activity of the human ICAM-2 promoter is contained within a small (0.33-kilobase (kbp)) 5'-flanking region of the gene. Here we describe the in vitro characterization of this region. The ICAM-2 promoter is TATA-less, and transcription in endothelial cells initiates at four sites.

1989年5月4日 · We have cloned this second ligand, designated ICAM-2, using a novel method for identifying ligands of adhesion molecules. ICAM-2 is an integral membrane protein with two immunoglobulin-like...

Intercellular adhesion molecule 2 is a protein in humans that is encoded by ICAM2 gene. ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion.