2023年7月7日 · We discovered that decreasing TCR/costimulation signal strength by incremental reduction of αCD3/costimulation beads progressively altered Th17 phenotype. Moreover, Th17 cells stimulated with αCD3/inducible costimulator (ICOS) beads produced more IL-17A, IFNγ, IL-2, and IL-22 than those stimulated with αCD3/CD28 beads.

The interaction of the inducible co-stimulator (ICOS) with its ligand (ICOSL) plays key roles in T-cell differentiation and activation of T-cell to B-cell functions. The ICOS/ICOSL pathway is a validated target for T-cell lymphomas induced by the ...

2024年8月22日 · 诱导性T细胞共刺激因子（ICOS，CD278）是一种激活性共刺激免疫检查点，在活化的T细胞上表达。 可诱导T细胞的增殖、存活和分化，并调节多种T细胞功能。 其配体ICOSL在抗原呈递细胞和体细胞上表达，包括肿瘤微环境中的肿瘤细胞。 ICOS与其配体的结合触发下游通路，从而调节T细胞增殖和存活，ICOS可作为预测和监测T细胞介导的免疫治疗反应的生物标志物。 ICOS的结构. ICOS是一种I型跨膜糖蛋白，它由199个氨基酸构成，具有一个可变区免疫球 …

2023年12月19日 · An instrument to measure time-resolved UV–Vis absorption spectra from small protein crystals using a pump-probe scheme with microsecond-to-second delays has been developed at the icOS Lab as a preparative tool for time-resolved serial synchrotron crystallography experiments.

Inducible T-cell costimulator (ICOS) is a homodimeric protein expressed on the surface of activated T-cells [1]. ICOS is critical for T-helper cell activation and proliferation [2, 3] and may play a protective role in inflammatory autoimmune diseases through Th2 cytokine induction [3].

2020年1月1日 · Inducible T cell costimulator (ICOS, cluster of differentiation (CD278)) is an activating costimulatory immune checkpoint expressed on activated T cells. Its ligand, ICOSL is expressed on antigen-presenting cells and somatic cells, including tumour cells in the tumour microenvironment.

2020年10月8日 · Here, we report the crystal structure of the co-complex between human ICOS and its ligand ICOS-L at 3.3 Å resolution, which reveals the molecular details of immune receptor specificity....

2020年12月1日 · CD3 + ICOS costimulation alters the fate of ICOS to be recycled rather than degraded in lysosomes. ICOS internalization is PI3K and clathrin mediated. The role of the inducible costimulatory of T cells (ICOS) has been shown to be important for many different T cell outcomes and is indispensable for follicular helper T cell (T FH) responses.

icos和icosl相互作用诱导的自体ilc3s与b细胞的直接接触促进了ilc3s的激活，这是由cd40信号协同介导的，表明ilc3s在免疫微环境中的独特和非冗余作用。 发布于 2023-10-09 10:19 ・IP 属地山东

This review summarises the biological background and rationale for targeting ICOS/ICOSL in cancer together with an overview of the principal ongoing clinical trials that are testing it in combination with anti-cytotoxic T lymphocyte antigen-4 and anti-programmed cell death-1 or anti-programmed cell death ligand-1 based immune checkpoint blockade.