ICOS + Tregs: A Functional Subset of Tregs in Immune Diseases
2020年8月28日 · In this review, we discuss the complicated role of ICOS + Tregs in several classical autoimmune diseases, allergic diseases, and cancers and investigate the related therapeutic applications in these diseases. Moreover, we identify ICOS as a potential biomarker for disease treatment and prognostic prediction.
ICOS+ Tregs: A Functional Subset of Tregs in Immune Diseases
In this review, we discuss the complicated role of ICOS + Tregs in several classical autoimmune diseases, allergic diseases, and cancers and investigate the related therapeutic applications in these diseases. Moreover, we identify ICOS as a potential biomarker for disease treatment and prognostic prediction.
诱导型T细胞共刺激因子ICOS - mabnus.cn
2024年8月22日 · 诱导性T细胞共刺激因子（ICOS，CD278）是一种激活性共刺激免疫检查点，在活化的T细胞上表达。 可诱导T细胞的增殖、存活和分化，并调节多种T细胞功能。
Regulatory T cells, especially ICOS - Nature
2016年10月11日 · In mice, ICOS + Tregs are characterized by superior survival and highly suppressive properties compared with ICOS − Tregs 19. Strauss et al. reported that ICOS + Tregs are the main...
靶点布局 | ICOS靶点能否成为肿瘤免疫治疗的新星？ - 知乎
多种疾病的动物模型研究表明，可诱导共刺激受体（ICOS）在自免和肿瘤免疫中都有应用，并且以ICOS途径为靶点的免疫调节对包括自身免疫性疾病及移植免疫的长期耐受的形成，均有着重要的临床应用意义。
可诱导T细胞共刺激分子：免疫刺激或免疫抑制的目标？
2018年3月13日 · 由于在维持T细胞活化和效应因子功能以及其与Treg抑制关系中的双重作用，靶向ICOS/ICOS-L代表了增强抗肿瘤免疫性的有效方法。 在临床中，结肠癌患者表现出ICOS的下降，而肿瘤中ICOS的表达与黑素瘤患者更高的存活率相关。
ICOS + Tregs：免疫疾病中Tregs的功能子集。,Frontiers in …
Recent studies have reported the pathological effect of ICOS+ T cells, but ICOS signals also widely participate in anti-inflammatory responses, particularly ICOS+ regulatory T (Treg) cells. The ICOS signaling pathway endows Tregs with increased generation, proliferation, and …
均受困于Treg，但ICOS没有PD-1“幸运”|细胞|剂量|临床|肿瘤|-健康界
2022年11月9日 · ICOS-ICOSL的基础生物学 诱导性T细胞共刺激因子 (ICOS/CD278)是一种激活的共刺激免疫检查点，在激活的T细胞上表达。 它的配体，ICOSL在抗原提呈细胞和体细胞上表达，包括肿瘤微环境中的肿瘤细胞。
Deciphering Novel Communication Patterns in T Regulatory Cells …
5 天之前 · Regulatory T cells (Tregs) are important in maintaining tolerance and are key players in immunity. In aging, increased Treg function along with low-grade inflammation has been reported. This dichotomy of enhanced Treg function along with inflammation highlights the importance of understanding Treg biology and communication patterns in the …
ICOS Regulates the Generation and Function of Human CD4+ Treg …
2013年12月2日 · By inhibiting the endocytosis of CTLA-4 with E64 and pepstatin A, the function of CD4 hi Treg could be partly reversed. Taken together, our results demonstrate the beneficial roles of ICOS in the generation of functional human CD4 + Treg and a …