2020年10月8日 · Here, we report the crystal structure of the co-complex between human ICOS and its ligand ICOS-L at 3.3 Å resolution, which reveals the molecular details of immune …

多种疾病的动物模型研究表明，可诱导共刺激受体（ICOS）在自免和肿瘤免疫中都有应用，并且以ICOS途径为靶点的免疫调节对包括自身免疫性疾病及移植免疫的长期耐受的形成，均有着重 …

Here, we reasoned that ICOS ligand (ICOSL) present on dendritic cells (DCs) that prime T cell responses may provide the key stimulus for generating pathogenic IL-17–producing, CD4 + …

2022年4月13日 · We have identified PD-L1 high ICOSL low Secretory cDC in vivo in inflamed HNSCC, and PD-L1 int ICOSL int immature DC in blood and as rare cells infiltrating non …

ICOS在活化的T细胞上表达，而其配体ICOSL在APCs如B细胞、巨噬细胞、单核细胞和树突状细胞（DC）上表达。 ICOS与ICOSL的相互作用介导T细胞活化和增殖，参与T细胞依赖性B细胞活 …

2024年12月12日 · 树突状细胞 (DC) 是免疫和耐受之间平衡的重要守门人。 它们有两种功能状态，未成熟或成熟，分别指信息感知状态和信息传输状态。 DC 成熟时，在被病原体或组织损伤 …

We report that cell surface expression of Inducible T-cell Costimulator Ligand (ICOSL) is selectively reduced on DCs from melanoma patients and partially regulated by canonical NF …

2020年11月4日 · ICOSL surface expression on patient AdVTMM2/DC correlated positively to their in vivo ability to induce tyrosinase-specific CD8 + T cell responses. Increased sICOSL also …

2016年6月2日 · 祁海教授指出，ICOSL（inducible T-cell co-stimulator ligand, also known as ICOSLG，诱导T细胞共刺激配体）不仅促进了TFH细胞发育，还调控了B细胞竞争性参与生发 …

Main findings: ICOS/ICOS-L signal has opposite effects on the T-cell response. ICOS-L is activated in several types of cancers to maintain immunosuppressive CD4+ T cell subsets, …