ICOSLG delivers a potent co-stimulatory signal to T cells when engaged by ICOS, resulting in T cell activation and proliferation. The existence of ICOS/ICOSLG signal in vivo is closely associated with many mouse autoimmune disease models. Conversely, the absence of ICOS/ICOSLG signal may be a good way to relieve autoimmune disease.

2025年3月30日 · ICOSLG (Inducible T Cell Costimulator Ligand) is a Protein Coding gene. Diseases associated with ICOSLG include Immunodeficiency 119 and Dyskeratosis Congenita, Autosomal Dominant 6. Among its related pathways are CD28 Signaling in T-Helper Cell and Immune response NFAT in immune response.

2025年2月8日 · ICOSLG acts as an oncogene to promote glycolysis, proliferation, migration, and invasion in gastric cancer cells. Role of the co-stimulatory molecule inducible T-cell co-stimulator ligand (ICOSL) in the progression of experimental …

ICOSLG（Inducible T-cell COStimulator Ligand），也称为B7-H2或CD275，是一种免疫检查点分子跨膜蛋白，通常由抗原呈递细胞（如抗原呈递的树突状细胞）和B细胞表达。 其分子结构包括一个Ig-like V型结构域，用于与其受体ICOS结合，以及跨膜区域和细胞内结构域。

Ubiquitous expression in brain (RPKM 4.2), lymph node (RPKM 3.4) and 23 other tissues. 实现相同的蛋白质结合活性。 预计参与 T 细胞受体信号通路和白细胞介素 4 产生的正调控。 位于细胞质核糖核蛋白颗粒和质膜。 [由基因组资源联盟提供，2022 年 4 月] Enables identical protein binding activity. Predicted to be involved in T cell receptor signaling pathway and positive regulation of interleukin-4 production.

2019年10月21日 · Inducible T-cell co-stimulator ligand (ICOSLG) is a member of the B7 family of immune regulatory ligands, expression of which in cancer is implicated in disease progression due to regulation of antitumor adaptive immunity.

ICOSLG is an immune checkpoint expressed by antigen-presenting cells (APC) as well as non-lymphoid cells including mesenchymal stem cells, endothelial cells, fibroblasts, and tumor cells …

2023年10月27日 · ICOS（Inducible T-cell Costimulator）是T细胞上的共刺激分子，与ICOSLG发生配体-受体结合后，可以提供正向信号，促进T细胞的增殖、存活和功能发挥。 ICOS/ICOSLG信号通路在调节T细胞的免疫应答中起着重要作用。 通过ICOS/ICOSLG信号，T细胞可以增强其对抗原的识别和应答能力，促进T细胞的活化和效应功能的发挥。 此外，ICOS/ICOSLG信号通路还参与调节体液免疫和细胞免疫的平衡。 它在刺激B细胞产生抗体、调节T细胞亚群平衡以及免疫耐 …

2016年6月2日 · 祁海教授指出，ICOSL（inducible T-cell co-stimulator ligand, also known as ICOSLG，诱导T细胞共刺激配体）不仅促进了TFH细胞发育，还调控了B细胞竞争性参与生发中心反应及形成浆细胞的过程。

2020年3月5日 · Inducible T-cell co-stimulator ligand (ICOSLG) is a member of the B7 family of immune regulatory ligands, expression of which in cancer is implicated in disease progression due to regulation of antitumor adaptive immunity.