ICOSLG delivers a potent co-stimulatory signal to T cells when engaged by ICOS, resulting in T cell activation and proliferation. The existence of ICOS/ICOSLG signal in vivo is closely …

Mar 30, 2025 · ICOSLG (Inducible T Cell Costimulator Ligand) is a Protein Coding gene. Diseases associated with ICOSLG include Immunodeficiency 119 and Dyskeratosis …

Feb 8, 2025 · ICOSLG acts as an oncogene to promote glycolysis, proliferation, migration, and invasion in gastric cancer cells. Role of the co-stimulatory molecule inducible T-cell co …

ICOSLG（Inducible T-cell COStimulator Ligand），也称为B7-H2或CD275，是一种免疫检查点分子跨膜蛋白，通常由抗原呈递细胞（如抗原呈递的树突状细胞）和B细胞表达。 其分子结构包 …

Ubiquitous expression in brain (RPKM 4.2), lymph node (RPKM 3.4) and 23 other tissues. 实现相同的蛋白质结合活性。 预计参与 T 细胞受体信号通路和白细胞介素 4 产生的正调控。 位于细 …

ICOSLG is an immune checkpoint expressed by antigen-presenting cells (APC) as well as non-lymphoid cells including mesenchymal stem cells, endothelial cells, fibroblasts, and tumor cells …

Oct 27, 2023 · ICOS（Inducible T-cell Costimulator）是T细胞上的共刺激分子，与ICOSLG发生配体-受体结合后，可以提供正向信号，促进T细胞的增殖、存活和功能发挥。 ICOS/ICOSLG信 …

祁海教授指出，ICOSL（inducible T-cell co-stimulator ligand, also known as ICOSLG，诱导T细胞共刺激配体）不仅促进了TFH细胞发育，还调控了B细胞竞争性参与生发中心反应及形成浆细 …

Sep 28, 2023 · In this study, we investigated the expression pattern of ICOSLG in oral squamous cell carcinoma, including tumor cells (TCs), cancer-associated fibroblasts (CAFs) and tumor …

Mar 5, 2020 · Inducible T-cell co-stimulator ligand (ICOSLG) is a member of the B7 family of immune regulatory ligands, expression of which in cancer is implicated in disease progression …