A role for Id in the regulation of TGF- β -induced epithelial
2004年6月4日 · Here, we demonstrate a central role of helix–loop–helix factors, E2A and inhibitor of differentiation (Id) proteins, in TGF- β -induced EMT. Epithelial cells ectopically expressing …
Id2 and Id3 define the potency of cell proliferation and ...
Transforming growth factors beta (TGF-betas) inhibit growth of epithelial cells and induce differentiation changes, such as epithelial-mesenchymal transition (EMT). On the other hand, …
TGF-β-induced epithelial to mesenchymal transition
2009年1月20日 · EMT illustrates the differentiation plasticity during development and is complemented by another process, called mesenchymal to epithelial transition (MET). While …
Id2 and Id3 Define the Potency of Cell Proliferation and ...
Our evidence supports a model whereby Id2/3 regulation renders TGF-β capable of eliciting EMT, whereas it waives such an instructive role from BMP. For the first time, we demonstrate that …
ID2 promotes tumor progression and metastasis in thyroid cancer
2024年1月10日 · We found that ID2 significantly promotes thyroid cancer cell proliferation, migration, EMT, and stemness through the PI3K/Akt pathway. Moreover, ID2 plays a crucial …
The ID proteins: master regulators of cancer stem cells and tumour ...
2014年1月20日 · By increasing ID1 levels, these oncogenic networks promote NSCLC cell proliferation, epithelial-to-mesenchymal transition (EMT; a process that renders tumour cells …
鼻咽癌相关基因ID2与EMT关系的初步探讨 - 百度学术
为了阐明ID2基因在鼻咽癌发病中的作用,我们利用RNAi技术高效、特异的靶向沉默机制干扰鼻咽癌细胞SUNE1中ID2表达,建立稳定靶向干扰ID2表达的siRNA鼻咽癌细胞,以观察干扰ID2后鼻咽 …
分化抑制因子2的生物学功能及其在乳腺癌中的研究进展_百度文库
【摘要】 分化抑制因子 2 （ ID2 ） 属螺旋环螺旋蛋白（ HLH） 的 ID 蛋白家族的一员，调控乳腺癌的 上皮间质转化（ EMT） ， 并影响乳腺癌患者的预后 。 而 ID2 与 HLH 家族成员之间的 …
BMP4 promotes metastasis of hepatocellular carcinoma by an …
2017年4月1日 · ID2 was up-regulated by recombinant human BMP4, resulting in HCC EMT. Knockdown of ID2 blocked BMP4-induced EMT. In conclusion, BMP4 promotes invasion and …
ID1 mediates escape from TGF-β tumor suppression in pancreatic …
ID1 inhibits the activation of E12/E47 (E) dependent pro-apoptotic genes, thus decoupling EMT from apoptosis and allowing PDA cells to survive while retaining the ability to undergo EMT. …