2024年12月25日 · ID2 (Inhibitor Of DNA Binding 2) is a Protein Coding gene. Diseases associated with ID2 include Ewing Sarcoma and Retinoblastoma. Among its related pathways are Signaling by NTRKs and Nuclear Events (kinase and transcription factor activation).

DNA-binding protein inhibitor ID-2 is a protein that in humans is encoded by the ID2 gene. [5] The protein encoded by this gene belongs to the inhibitor of DNA binding (ID) family, members of which are transcriptional regulators that contain a helix …

2017年1月25日 · In colon adenocarcinoma the Id2 gene is a target of the β-catenin/T-cell factor transcription pathway and induces the clonogenic growth of the colon cells . In neuroblastoma the Id2 gene is activated by Myc oncoproteins, which leads to the inhibition of the pRb tumor suppressor pathway with consequent cell-cycle progression [ 115 ].

2006年11月5日 · Our data emphasize the importance of Id2 in regulating gene expression by CD8 + T cells and the magnitude of effector responses, suggesting a mechanism involving Id protein– and E...

ID2-AS1 significantly suppressed the migration, invasion and metastasis of hepatocellular carcinoma (HCC) cells in vitro and in vivo. Mechanistically, ID2-AS1 regulated the transcription of its adjacent gene inhibitor of DNA binding 2 (ID2) by blocking the binding of histone deacetylase 8 (HDAC8) on the ID2 enhancer

The protein encoded by this gene belongs to the inhibitor of DNA binding family, members of which are transcriptional re gulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the inhibitor of DNA binding family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner ...

2022年4月14日 · In the current study, we used gene expression data from this model system to identify that Inhibitor of DNA Binding 2 (ID2) (previously known as Inhibitor of Differentiation 2), which is a...

DNA 结合抑制剂家族的成员通过 HLH 结构域抑制它们的异二聚化伙伴，以显性负性方式抑制基本螺旋-环-螺旋转录因子的功能。 这种蛋白质可能在负向调节细胞分化中发挥作用。 该基因的假基因位于 3 号染色体上。 [RefSeq 提供，2011 年 8 月] The protein encoded by this gene belongs to the inhibitor of DNA binding family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain.

Orphan nuclear receptor small heterodimer partner, a novel corepressor for a basic helix-loop-helix transcription factor BETA2/neuroD. The transcriptional repressor ID2 can interact with the canonical clock components CLOCK and BMAL1 and …

2024年6月17日 · Inhibitor of DNA binding 2 (ID2) regulates the expression of developmental genes and tumorigenesis in ewing sarcoma. Koppenhafer SL, Goss KL, Voigt E, Croushore E, Terry WW, Ostergaard J, Gordon PM, Gordon DJKoppenhafer SL, et al .