2024年1月29日 · Mechanistically, through its HLH domain, Id2 binds and disrupts the assembly of the Tcf3-Tal1 transcriptional regulatory complex, and thus modulates chromatin accessibility at …

DNA-binding protein inhibitor ID-2 is a protein that in humans is encoded by the ID2 gene. [5] The protein encoded by this gene belongs to the inhibitor of DNA binding (ID) family, members of …

In contrast to the effects of Id2 on differentiation and cell proliferation, Id2-mediated apoptosis is independent of HLH-mediated dimerization. The ability of Id2 to promote cell death resides in …

Inhibitor of binding or differentiation 2 (Id2), a member of helix-loop-helix (HLH) transcriptional factors, is recently reported as an important regulator of the development or differentiation of …

2024年12月25日 · ID2 (Inhibitor Of DNA Binding 2) is a Protein Coding gene. Diseases associated with ID2 include Ewing Sarcoma and Retinoblastoma. Among its related pathways …

2016年7月11日 · In the current issue of Cancer Cell, Ghisi and colleagues (2016) report their discovery of the helix-loop-helix (HLH) transcription factors E2-2 (or TCF4) and ID2 (for …

dna 结合抑制剂家族的成员通过 hlh 结构域抑制它们的异二聚化伙伴，以显性负性方式抑制基本螺旋-环-螺旋转录因子的功能。 这种蛋白质可能在负向调节细胞分化中发挥作用。

2005年7月20日 · There are four known members of the Id family in vertebrates (called ID1, ID2, ID3 and ID4) that belong to the helix-loop-helix (HLH) family of transcription factors. Positively …

ID2 expression affects the susceptibility hepatoma cell lines to an HDAC inhibitor by regulating the expression of anti-apoptotic genes. Id2 induces squamous cell carcinoma tumor growth and …

2018年4月7日 · The inhibitor of DNA binding and cell differentiation 2 (Id2) is a helix-loop-helix (HLH) protein that acts as negative dominant regulator of basic-HLH transcription factors …