“想”发育成前感觉贴片者上调Jag1和Lfng这两种Notch 1配体的表达。 LFNG通过选择性糖基化Notch 1，抑制后者与JAG1结合，但是否影响Notch？ 和JAG1结合尚不清楚。

2006年11月1日 · In Drosophila, the expression of Notch, delta (a Notch ligand) and fringe (a homologue of LFNG) regulates boundary formation such that cells that express all three molecules are refractory to ...

2024年2月11日 · Notch信号通路可以调控B细胞中转录因子的活性。例如，持续表达Notch1细胞内结构域的B细胞表达Id2增加，抑制了E蛋白如E2A的功能。此外，如上所述，造血祖细胞中的Notch信号通过MAP激酶磷酸化引发的E2A下游降解导致E2A的降解。

The first clear indication of AP asymmetry of the chicken and mouse ear rudiment is the regionalized expression of genes, such as Lunatic fringe (Lfng), Fgf10, Six1, and Sox2, strongly in the anterior but more weakly and diffusely in the posterior region of the otic cup (Morsli et al. 1998; Cole et al. 2000; Zheng et al. 2003; Alsina et al ...

2010年11月10日 · Expression of a known BMP target gene, Id2 (Hollnagel et al., 1999), appears to correlate well with phospho-SMAD levels in the cochlea at E13.5 (Fig. 1 F,G, right). These results suggest that a gradient of BMP signaling across the abneural–neural axis of the cochlear duct is progressively established during cochlear outgrowth.

LFNG (lunatic fringe)是Notch信号通路中的一个关键基因，编码一种糖基转移酶，能识别并糖基化修饰Notch受体上EGF (epithelial growth factor)重复序列，参与调控多种肿瘤、支气管哮喘和软骨发育不全等多种疾病的发生发展过程。 本文就近年来关于Notch信号通路中的关键基因 LFNG 的功能研究作一综述。 引用本文: 洪玲, 张树冰. Notch信号通路中关键基因Lunatic Fringe功能的研究进展 [J] . 国际遗传学杂志, 2018, 41 (5) : 384-390. DOI: 10.3760/cma.j.issn.1673 …

2023年3月10日 · lfng作为一种糖基转移酶，可以在翻译后修饰notch的胞外结构域，周期性地阻断notch受体的切割，导致环状nicd 的形成。 PSM是一组自持振荡单元，但其间的同步振荡，取决于NOTCH信号的传输。

Members of the inhibitor of DNA binding family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by suppressing their heterodimerization partners through the HLH domains. This protein may play a …

2020年4月15日 · Here, we show that conditional knockout of Id1/2/3 genes (Id TKO) causes major defects in morphogenesis and cellular patterning in the development of mammalian cochlea. Id TKO cochlea was 82% shorter than control, and both decreased proliferation and increased cell death caused the hypomorph.

Notch signaling can regulate transcription factor activity in B cells. For instance, B cells constitutively-expressing the Notch1 intracellular domain have elevated expression of Id2, which inhibits the function of E proteins such as E2A .