2015年8月6日 · Idarucizumab rapidly and completely reversed the anticoagulant effect of dabigatran in 88 to 98% of the patients who had had elevated clotting times at baseline.

2024年12月17日 · Idarucizumab is a drug that reverses the effects of another medicine called dabigatran (Pradaxa). Dabigatran is used to prevent blood clots and strokes in people with certain heart disorders. Because the medicine keeps the blood from clotting, people taking dabigatran can bleed more easily.

Idarucizumab, sold under the brand name Praxbind, is a monoclonal antibody used as a reversal agent for dabigatran. [4] Idarucizumab was developed by Boehringer Ingelheim. One study sponsored by the manufacturer found that idarucizumab effectively reversed anticoagulation caused by dabigatran within minutes. [6]

2015年10月27日 · Approved under the tradename Praxbind (FDA), idarucizumab is indicated for the emergency treatment of dabigatran-associated bleeding in life-threatening or surgically induced situations. Its use is associated with immediate, complete and sustained reversal of the anticoagulant effects of dabigatran.

Medscape - Dabigatran reversal dosing for Praxbind (idarucizumab), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost...

Idarucizumab (Praxbind) is used in patients treated with dabigatran (Pradaxa) when reversal of the anticoagulant effects is needed for emergency surgery or urgent procedures, or in the event of life-threatening or uncontrolled bleeding. Learn about uses, side effects, drug interactions, dosages, warnings, and more.

2023年6月29日 · Idarucizumab (Praxbind) is an antibody used for reversing the effect of Pradaxa (dabigatran) for emergency surgery/urgent procedures or if life-threatening or uncontrolled bleeding occurs while taking dabigatran.

Idarucizumab, a specific reversal agent for dabigatran, is a humanized monoclonal antibody fragment (Fab) that binds specifically to dabigatran and its acylglucuronide metabolites with an affinity for dabigatran that is ~350 times greater than that of thrombin, and neutralizes the anticoagulant effect within minutes (Das 2015; Schiele 2013).

2024年1月31日 · Idarucizumab injection is used in patients who are taking dabigatran (a blood thinner) during emergency or life-threatening situations when bleeding cannot be controlled. This medicine is to be given only by or under the direct supervision of your doctor.

2024年6月10日 · Specific reversal agent for anticoagulant effects of dabigatran; recombinant humanized monoclonal antibody fragment capable of binding dabigatran.