Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, …
2020年11月18日 · We found that inhibiting TNF-α and IFN-γ protected against death in SARS-CoV-2 infection and models of sepsis, hemophagocytic lymphohistiocytosis (HLH), and …
经典的TNF信号通路 - 知乎 - 知乎专栏
TNF （Tumor Necrosis Factor）又称TNFα，是一种能直接杀伤肿瘤细胞且对正常细胞无明显细胞毒性的细胞因子，是一种参与全身炎症的细胞信号蛋白，是构成急性期反应的细胞因子之一。 …
肿瘤坏死因子α(TNF-α)作用机制及生物学研究 - 知乎
TNF-α可通过激活中性粒细胞和血小板、增强巨噬细胞/NK细胞的杀伤能力以及刺激免疫系统来增强感染抵抗力，还可在多种自身免疫性疾病中发挥病理作用，如 移植物抗宿主排斥反应 和 类 …
TNF-mediated inflammatory disease - PubMed
TNF was originally described as a circulating factor that can cause necrosis of tumours, but has since been identified as a key regulator of the inflammatory response. This review describes …
IFN-γ-Induced TNF-α Expression Is Regulated by Interferon …
2008年10月1日 · In this study, we report that TNF-α production is induced by IFN-γ treatment in the murine macrophage cell line RAW 264.7. TNF-α mRNA levels are increased in cells …
COVID-19 patients with high TNF/IFN-γ levels show hallmarks of ...
2023年11月1日 · Our data showed that in COVID-19 patients, the TNF/IFN-γ co-signaling influences activate cell cycle arrest, senescence, and cell death that converge to favor …
肿瘤坏死因子（tumor necrosis factor，TNF） - 知乎专栏
最近有人报道通过基因工程技术表达了N端少2个氨基酸（Val、Arg）的155氨基酸人TNF-α，具有更好的生物学活性和抗肿瘤效应。 此外，还有用基因工程方法，将TNF-α分子氨基端7个氨基 …
TNF plays a crucial role in inflammation by signaling via T cell ... - PNAS
2021年12月6日 · We found that TNF shapes the inflammatory response by signaling via its relatively unstudied “minor” receptor, TNFR2, skewing T cells to become inflammatory Th17 …
Tumor necrosis factor and interferon: cytokines in harmony
2008年7月1日 · One of the first responses against viral infections is the production of anti-viral cytokines, including interferons (IFNs), and tumor necrosis factor (TNF). Once produced, …
Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue ...
2021年1月7日 · We found that inhibiting TNF-α and IFN-γ protected against death in SARS-CoV-2 infection and models of sepsis, hemophagocytic lymphohistiocytosis (HLH), and cytokine …