2024年12月25日 · IFI35 (Interferon Induced Protein 35) is a Protein Coding gene. Diseases associated with IFI35 include Stomatitis and Mouth Disease. Among its related pathways are Cytokine Signaling in Immune system and Antiviral mechanism by IFN-stimulated genes. An important paralog of this gene is NMI.

2025年2月18日 · IFI35是一种干扰素诱导蛋白，在多种免疫细胞中表达，但其在肿瘤免疫中的作用尚不明确。 本研究旨在探讨IFI35在TNBC中的作用及其潜在机制。 研究结果表明，IFI35通过促进CCL2的分泌，抑制了TNBC中的抗肿瘤免疫反应，从而促进了肿瘤的进展。 这些发现为TNBC的免疫治疗提供了新的靶点。 三阴性乳腺癌（TNBC）是一种高度侵袭性的乳腺癌亚型，其特点是缺乏雌激素受体（ER）、孕激素受体（PR）和人表皮生长因子受体2（HER2）的表达。 由于缺 …

70110 Ensembl ENSG00000068079 ENSMUSG00000010358 UniProt P80217 Q9D8C4 RefSeq (mRNA) NM_005533 NM_001330230 NM_027320 RefSeq (protein) NP_001317159 NP_005524 NP_081596 Location (UCSC) Chr 17: 43.01 – 43.01 Mb Chr 11: 101.34 – 101.35 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Interferon-induced 35 kDa protein is a protein that in humans is encoded by the IFI35 gene ...

Enables identical protein binding activity. Involved in several processes, including macrophage activation involved in immune response; positive regulation of defense response; and regulation of signal transduction.

2024年4月9日 · IFI35 induced non-canonical NF-kB signaling through proteasomal processing of p105 to the DNA-binding transcription factor p50, which heterodimerizes with RELB (RELB/p50), and activated...

2021年5月10日 · IFI35 deficient mice accordingly exhibit more resistance to lethal H7N9 infection than their wild-type control exhibit. Our data uncover a novel mechanism by which IFI35 regulates RIG-I-mediated anti-viral immunity through mutual antagonism with influenza protein NS1.

interferon-induced 35 kDa protein, IFP 35, ifi-35. IFP35 family proteins promote neuroinflammation and multiple sclerosis. IFI35 as a biomolecular marker of neuroinflammation and treatment response in multiple sclerosis. IFI35 enhances proliferation of mesangial cells and is regulated by MBD2 in lupus nephritis.

2023年6月28日 · Our findings identify IFI35 as a new biomarker that can enhance the proliferation and function of CD8 + T cells, as well as increase the efficacy of CAR-T cells against colorectal cancer cells.

2025年2月8日 · Enables identical protein binding activity. Involved in several processes, including macrophage activation involved in immune response; negative regulation of non-canonical NF-kappaB signal transduction; and positive regulation of defense response.

However, the role of IFN-induced 35-kDa protein 35 (IFI35), a type I IFN-dependent transcript, in glomerular inflammation is unclear. Here, we aimed to investigate the expression and the role of IFI35 in IFN-β/retinoic acid-inducible gene-I (RIG-I)/CCL5 and IFN-β/melanoma differentiation-associated gene 5 (MDA5)/CXCL10 axes in MCs.