2024年12月25日 · Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs.

Interferon-induced protein with tetratricopeptide repeats 1 is a protein that in humans is encoded by the IFIT1 gene. [4] [5] [6]

IFIT1 is an IFN-induced highly expressed protein that functions in the cytoplasm as a dual sensor and effector molecule to restrict virus infection. You might find these chapters and articles relevant to this topic.

IFIT1 modulates the proliferation, migration and invasion of pancreatic cancer cells via Wnt/beta-catenin signaling. Kruppel-like factor 13 acts as a tumor suppressor in thyroid carcinoma by downregulating IFIT1.

2012年12月14日 · This report showed that IFIT1 binds to the free 5′-ppp moiety on viral RNA from vesicular stomatitis virus, Rift Valley fever virus and influenza A virus and inhibits their infection by forming...

In a genome-wide small interfering RNA (siRNA) screen of the LPS-induced tumor necrosis factor α (TNF-α) response in macrophages, we identify the interferon-stimulated protein IFIT1 as a negative regulator of the inflammatory gene program.

2011年6月5日 · Nature Immunology - The antiviral protein IFIT1 is upregulated substantially in the cytoplasm of virus-infected cells. Superti-Furga and colleagues show that IFIT1 is part of a...

IFIT proteins (Interferon Induced proteins with tetratricopeptide repeats) are produced in the human body and are supposed to confer immunity against viral infections.

This review focuses on the recent cellular, biochemical, and structural discoveries that have provided new insight as to how IFIT1 functions as both a sensor and effector molecule of the cellular innate immune system.

2025年1月16日 · The Ifit1 gene is a key component in the body’s defense against viral infections, playing a role in innate immunity as an early responder to pathogenic threats. Understanding its function and interaction with viruses can help researchers develop strategies to …