2024年12月25日 · IFIT2 (Interferon Induced Protein With Tetratricopeptide Repeats 2) is a Protein Coding gene. Diseases associated with IFIT2 include Microphthalmia With Limb Anomalies and Aicardi-Goutieres Syndrome. Among its related pathways are Overview of interferons-mediated signaling pathway and Cytokine Signaling in Immune system.

2013年10月1日 · In this study, we report the generation of mice deficient in IFN-induced protein with tetratricopeptide repeats 2 (Ifit2) and demonstrate that Ifit2 is a critical signaling intermediate for LPS-induced septic shock.

Interferon-induced protein with tetratricopeptide repeats 2 (commonly termed IFIT2) is a protein that in humans is directed to be produced by the IFIT2 gene.

ifit2是ifits家族中十分重要的一名成员，其编码基因ifit2大多数定位在细胞质内，少数位于细胞核及内质网中[5]，ifit2基因通常处于沉默或者一个极低的基础表达水平。

IFIT2, a protein responsible for interferon stimulation, may prevent oral squamous cell carcinoma (OSCC) metastasis and serve as a valuable prognostic marker. ISG54 binds specifically to some RNAs, such as adenylate uridylate (AU)-rich RNAs, with or without 5' triphosphorylation.

Enables RNA binding activity. Involved in negative regulation of protein binding activity; positive regulation of apoptotic process; and response to virus. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

2020年8月24日 · As opposed to suppressing infection, we show in the present study that IFIT2 is instead repurposed by influenza virus to promote viral gene expression. CLIP‐seq demonstrated that IFIT2 binds...

2019年12月19日 · 人类 ifit 基因家族由四个基因组成，分别称为 ifit1、ifit2、ifit3 和 ifit5。 IFIT 基因在大多数细胞类型中的表达非常低，而干扰素治疗、病毒感染和病原体相关分子模式 (PAMP) 大大增强了它们的表达。

2018年6月1日 · IFIT2 and IFIT3 homodimers dissociate to form a more stable heterodimer that also associates with IFIT1. We show for the first time that IFIT3 stabilizes IFIT1 protein expression, promotes IFIT1 binding to a cap0 Zika virus reporter mRNA and enhances IFIT1 translation inhibition.

2024年7月17日 · IFN-stimulated genes (IFIT2) is one such protein, which inhibits replication of many RNA viruses in the mouse brain and the resultant neuropathology. Our study sheds light on how IFIT2 works. By ablating Ifit2 expression only in neuronal cells, using a newly generated conditional knockout mouse line, we showed that Ifit2 induction in the ...