Interferon gamma (IFNG or IFN-γ) is a dimerized soluble cytokine that is the only member of the type II class of interferons. [5] The existence of this interferon, which early in its history was known as immune interferon, was described by E. F. Wheelock as a product of human leukocytes stimulated with phytohemagglutinin , and by others as a ...

干扰素-γ (interferon-γ，IFN-γ) 是细胞因子的一种，主要是T细胞和 NK 细胞等产生的一种促炎细胞因子.它拥有不同的免疫作用机制.在多个信号通路中产生免疫调节反应；IFN-γ具有广谱抗病毒、抗肿瘤…

ifn-γ 是一种重要的免疫调节因子，在抵抗感染、肿瘤免疫和炎症反应中发挥着关键作用。 它也与一些免疫缺陷疾病和自身免疫性疾病相关。 展开阅读全文

2024年1月29日 · ifn-γ信号通路 概述. 有生物活性的ifn-γ为可溶性同源二聚体细胞因子。ifn-γ二聚体与其细胞表面受体 ifngr1 （α亚基/cd119）结合并诱导ifngr1二聚化，再与2个 ifngr2 （β亚基）结合形成受体复合物。

2018年6月19日 · Domeier, P. P. et al. IFN-gamma receptor and STAT1 signaling in B cells are central to spontaneous germinal center formation and autoimmunity. J. Exp. Med. 213, 715–732 (2016).

干扰素-γ可以与 干扰素伽玛受体 （ 英语 ： Interferon-gamma receptor ） (IFNGR)结合，进而调节JAK-STAT通路。 干扰素-γ激活 抗原提呈细胞 ，通过上调 转录因子 T-bet而促进I型辅助T细胞(Th1细胞)的分化。

Interferon‐gamma (IFN‐γ) is a cytokine that plays an important role in inducing and modulating an array of immune responses. Cellular responses to IFN‐γ are mediated by its heterodimeric cell‐surface receptor (IFN‐γR), which activates downstream signal transduction cascades, ultimately leading to the regulation of gene expression.

2023年6月1日 · Interferon-gamma (IFN-γ) is a pleiotropic cytokine that plays a critical role in mediating an array of immune responses including promotes antiviral activity, facilitates macrophage activation, controls Th1/Th2 balance, and …

ifn-γ是一种多效性细胞因子，从慢性炎症的细胞转化、单核细胞/巨噬细胞，到抗肿瘤作用、细胞毒性t细胞（ctl）、th1、nk、nkt细胞，在免疫应答过程中可对宿主细胞产生相反的作用。ifn-γ的抗肿瘤作用也因肿瘤细胞的异质性和肿瘤微环境的不同而不同。

2018年5月30日 · A key player in driving cellular immunity, IFN-γ is capable of orchestrating numerous protective functions to heighten immune responses in infections and cancers. It can exhibit its immunomodulatory effects by enhancing antigen processing and presentation, increasing leukocyte trafficking, inducing …