2021年10月1日 · The IgE BCR has emerged as a critical B cell-intrinsic regulator of IgE responses through its antigen-independent signaling and low surface expression, predisposing IgE B cells towards short-lived PC differentiation and/or apoptosis, and limiting the ability of IgE B cells to compete in GCs.

2024年9月10日 · BCR triggering is the very first molecular event that ‘translates’ extracellular antigen binding to intracellular signalling. This intracellular signalling is BCR signalling, and it...

2021年12月7日 · Overall, our genome-wide CRISPR screens indicate that the chronic dynamics of IgE-BCR signaling translates into a distinct quality of calcium signaling in IgE + B cells and contributes to curtailing IgE + PC differentiation and survival.

1 天前 · Using fluorescent reporter mice for B cells poised to switch to IgE, we identified lung-resident allergen-specific IgG1 + MBCs as the major source of IgE-switching cells. B cell receptor (BCR) repertoire analysis revealed shared clones between IgG1 + MBCs and IgE + PCs in the lungs but little overlap between lung-resident MBCs and B cells in ...

2016年12月9日 · Here we reveal that IgE + B cells are constrained by chronic activity of the IgE B cell receptor (BCR). In the absence of cognate antigen, the IgE BCR promoted terminal differentiation of B cells into plasma cells (PCs) under cell culture conditions mimicking T cell help.

2024年12月1日 · IgE GC cells are unfit: they are highly apoptotic, express low levels of the B cell receptor (BCR) and various co-stimulatory molecules, and are under-represented in the light zone of the GC, suggesting impaired interactions with Tfh cells [21].

2019年4月18日 · Recent studies indicate that the IgE BCR has distinct signaling properties from the IgG1 BCR; in the absence of antigen, the IgE BCR seems to have increased basal signaling activity, and this was most highly associated with the extracellular membrane proximal domain, also known as the membrane Ig isotype-specific (migis) region, of IgE versus ...

3 小时之前 · 芝加哥洛约拉大学Yee Ling Wu研究小组报道了肺驻留记忆B细胞维持呼吸道的过敏性IgE反应。 ... 肺中主要的IgE类别转换，并鉴定出IgG1 + MBCs是产生IgE的细胞的前体，这得到了B细胞受体（BCR）库测序的支持。

B cell-intrinsic regulation of IgE is orchestrated by the IgE B Cell Receptor (BCR). Through its antigen-independent signaling and low surface expression, the IgE BCR drives IgE B cells to differentiate into short-lived plasma cells and/or undergo apoptosis, restricting IgE-expressing cells from entering long-lived compartments.

2015年8月10日 · We observed that IgM-BCR activation is dependent on mechanical forces and exhibits a multi-threshold effect. In contrast, the activation of isotype-switched IgG- or IgE-BCR only requires a low threshold of less than 12 pN, providing an explanation for their rapid activation in response to antigen stimulation.