2019年2月11日 · Immunoglobulin E (IgE) is an antibody produced during a type I hypersensitivity reaction to an allergen. (See DermNet's page Allergies explained.) A schematic for the type I reaction pathway is shown below [1]. IgE antibodies are normally found in small amounts in the blood. A higher level than normal infers an allergic disorder may be present [2].

2020年5月5日 · Serum specific IgE testing, also known as radioallergosorbent testing (RAST), is performed to detect allergen-specific IgE in the blood. Specific IgE ≥ 15 kU/L is highly predictive of peanut allergy [4]. These tests do not predict the severity of clinical allergy [4]. What is the differential diagnosis for peanut allergy?

Wiskott-Aldrich syndrome patients often have elevated IgE levels and develop allergies. Immunodeficiency may affect both T and B lymphocyte function. Immune deficiency increases the risk and frequency of a wide range of infections including discharging ears, bacterial or viral pneumonia, bacterial skin infections and herpes simplex (cold sore ...

What is a house dust mite? A house dust mite is an eight-legged arachnid with a three-month life cycle of egg, larva, protonymph, tritonymph, and adult stages.

A radioallergosorbent test (RAST) can be used to identify the causative allergen. This assay detects specific IgE antibodies against a range of common allergens. RAST has now largely been replaced by fluoroenzyme assays (eg, the ImmunoCAP assay), which are more sensitive at detecting allergen-specific IgE.

Waldenström macroglobulinaemia affects males a little more commonly than females, and usually in the age range 50–70 years (median age 63 years). The most common presenting symptoms are: Weight loss; Weakness; Tiredness; Common signs are: Anaemia; Enlarged lymph nodes; Enlarged liver and/or spleen; Intermittent bleeding from mucosa

The exact mechanism of dermographism is not known. Skin trauma may release an (as yet unidentified) antigen that reacts with the membrane-bound IgE on mast cells triggering release of histamine and other inflammatory mediators. Histamine causes local vasodilation and leaking of fluid from small blood vessels which leads to fluid accumulation in ...

Normal immunoglobulin-E antibodies (IgE) activate IgE receptors (FceRI) on mast cells and basophils. These cells release histamine, an important mediator in allergic responses. Autoimmune urticaria is due to autoantibodies that bind to either these receptors or the IgE antibodies themselves. This causes inappropriate activation of the mast ...

Patients with selective IgA deficiency have normal levels of all immunoglobulins except for IgA. Other components of the immune system such as phagocytes, complement proteins and T cells are normal. Selective IgA deficiency is one of the most common primary immunodeficiency diseases. It occurs in the Caucasian population in 1 in every 500–700 ...

White cell count and acute phase reactants are normal when symptom-free. In a study in Italy of 210 children fulfilling the criteria for PFAPA syndrome, 43 carried diagnostic mutations for a familial fever syndrome – mevalonate kinase deficiency (33), …