2018年11月30日 · Autoreactive IgG and IgM can be produced in warm AIHA; when bound to the erythrocyte, both are able to bind C1q and activate the classical complement pathway. C1 esterase inhibitor (C1-INH) is a commercially available inhibitor of the classical pathway licensed for hereditary angioedema with a favorable safety profile.

2021年3月11日 · Warm autoimmune hemolytic anemia (wAIHA) is the most prevalent form of autoimmune hemolytic anemia (AIHA), accounting for 60% to 70% of all cases. It is usually due to an immunoglobulin G (IgG) autoantibody that may activate complement (C) if present at high titer or if IgG1 and IgG3 subclasses are prevalent.

Autoimmune hemolytic anemia (AIHA) is a rare immune disorder. It happens when your body mistakes red blood cells as foreign substances and attacks them. Treatments include medication, surgery or, in rare cases, a blood transfusion. AIHA is highly manageable, but can be fatal if left untreated. Prompt care is critical.

Immune hemolytic anemia (IHA) is the clinical condition in which antibodies of immunoglobulin G (IgG) and/or immunoglobulin M (IgM) bind to red cell surface antigens and initiate red cell destruction via the complement system and the reticulo-endothelial system.

自身免疫性溶血性贫血（autoimmune hemolytic anemia, AIHA）是由于机体免疫功能紊乱、产生自身抗体、红细胞破坏加速（溶血）超过骨髓代偿时发生的贫血。 目前国内尚无AIHA流行病学的数据，国外资料显示AIHA的年发病率为（0.8~3.0）/10万 [1-2] 。

自身免疫性溶血性贫血 (AIHA) 定义为通过自身免疫机制对红细胞的破坏增加导致的贫血，通常由针对红细胞表面抗原的自身抗体所介导。 在过去的十年中，很少有关于病因、发病机制、诊断和治疗的重要新发现。 从历史上看，临床实践是基于理论考虑、病例报告和专家意见。 但最近，已经进行了几项前瞻性和其他系统的临床研究。 关于诊断和治疗的第一个国际共识于 2020 年发表，并且英国也发布了相关指南。 然而，挑战仍然存在，包括更广泛地应用现有知识、提高对发病 …

自身免疫性溶血性贫血（Autoimmune hemolytic anemia，AIHA）系体内免疫功能调节紊乱，产生自身抗体和（或）补体吸附于红细胞表面，通过抗原抗体反应加速红细胞破坏而引起的一种溶血性贫血。

2024年11月1日 · In wAIHA, IgG autoantibody reacts with autologous RBCs at 37 °C, leading to antibody-dependent cell-mediated cytotoxicity and increased phagocytosis of RBCs in the spleen. Cold AIHAs include cold...

2021年10月6日 · In warm autoimmune hemolytic anemia (AIHA), erythrocytes opsonized with immunoglobulin (typically IgG) are destroyed by the mononuclear phagocytic system, mainly in the spleen...

定义：自身免疫性溶血性贫血（autoimmune hemolytic anemia，AIHA）系体内B淋巴细胞免疫调节紊乱，产生自身抗体和（或）补体，并结合于红细胞膜上，致红细胞破坏加速而引起的一组溶血性贫血。