Transient pentameric IgM fulfill biological function—Effect of
2020年3月12日 · From our studies, we conclude that the transient expression system provides an attractive alternative for rapid, efficient and high-throughput production of complex IgM …
Cryomicroscopy reveals the structural basis for a flexible ... - Nature
2022年10月23日 · Here, we use cryo-EM to image the structure of the human full-length IgM pentamer, revealing antigen binding domains flexibly attached to the asymmetric and rigid …
Multimeric ACE2-IgM fusions as broadly active antivirals that …
2022年11月12日 · Fusion of ACE2 to IgM-Fc results in hexameric ACE2-IgM-Fc proteins with potent virus neutralization efficiency of patient-isolated SARS-CoV and SARS-CoV-2 variants.
High resolution imaging of IgG and IgM molecules by scanning tunneling ...
2011年12月1日 · We describe, here, high resolution imaging of individual IgM and IgG using a scanning tunneling microscope (Nama-STM) in air condition. The biomolecules were …
Architecture of Human IgM in Complex with P. falciparum …
2016年2月2日 · Microvascular binding mediated by PfEMP1 in complex with non-immune immunoglobulin M (IgM) is common among parasites that cause both severe childhood …
Epitope Mapping Services | Structural Biology CRO
Negative stain transmission electron microscopy (TEM) workflows offer additional analysis of antibody antigen complexes for epitope mapping. This technique involves staining the sample …
Prognostic role of mesangial IgM deposition in IgA nephropathy: …
2024年2月15日 · An independent pathologist evaluated the IgM immunofluorescence pattern, Oxford MEST-C score, and transmission electron microscopy (TEM) lesions following a …
The structure of oligomeric IgM in the absence of J chain. (A) The ...
Soluble immunoglobulin M (IgM) forms a pentamer containing a joining (J) chain polypeptide. While IgM pentamer has various immune functions, it also behaves as a carrier...
科普知识 | 一文了解IgM、IgG、IgA、IgE四种抗体 - 知乎
2023年7月5日 · IgM——第一道防线. B细胞活化后，生成的抗体大部分是“免疫球蛋白M”（IgM）。它们很可能是几亿年前就出现的最早一批抗体。IgM基本是5个抗体将尾端连在一起而形成 …
生命科学学院肖俊宇研究组解析人源免疫球蛋白M复合体的高分辨 …
2020年2月5日 · 免疫球蛋白M（IgM）是人体内五类免疫球蛋白之一，在免疫系统中发挥重要功能。IgM以多聚体的形式存在，而多聚体的形成对IgM黏附病原生物、激活补体系统等功能都具 …
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