The immunoglobulin superfamily (IgSF) is a large protein superfamily of cell surface and soluble proteins that are involved in the recognition, binding, or adhesion processes of cells. Molecules are categorized as members of this superfamily based on shared structural features with immunoglobulins (also known as antibodies); they all possess a ...

The immunoglobulin superfamily (IgSF) is comprised of proteins that contain at least one Ig domain. This motif characteristically occurs within the extracellular portions of proteins and frequently mediates recognition events. Indeed, the evolution of IgSF proteins appears to be linked to the development of multicellular organisms.

免疫球蛋白 超家族 （IgSF）指 分子结构 中有与免疫球蛋白类似的 结构域 的分子超家族，在细胞黏着中发挥作用。 在Ig的每个结构域中，都是由70～110个 氨基酸组成 的紧密折叠的结构。 后来在很多不同种类的 蛋白质 中也都发现有类Ig结构域的存在，这些结构同Ig抗体一起构成了免疫球蛋白超家族（immunoglobulins superfamily, IgSF）。 IgSF的大多数成员是 整合膜蛋白，存在于 淋巴细胞 的表面，参与各种免疫活动。 它们中的某些 整合蛋白 参与非钙依赖性的细胞之间的粘 …

2025年2月23日 · The Immunoglobulin superfamily (IgSF) is a heterogeneous and conserved family of adhesion proteins crucial during the development of the central nervous system including...

The immunoglobulin superfamily (IgSF) is a class of proteins that are associated with the adhesion, binding and recognition processes of cells. The term "immunoglobulin superfamily" (IgSF) initially referred to Igs and other proteins involved in the immune response and sharing the same 3D topology.

1992年6月1日 · Key words: Igsuperfamily/ adhesioncascades/ signal transduction/ inflammatory response/ metastasis/ deveopment / receptors THE IMMUNOGLOBULIN superfamily (IgSF) encompasses a diverse collection of molecules that share a …

2006年1月27日 · Structure of the Immunoglobulin (Ig) Superfamily Domains • Diversity of Functions of the Ig Domain • Evolution of the Ig Domain • Engineering of Ig Domains for Various Applications ...

2020年8月20日 · The IgSF is the largest and most functionally diverse family in the cell-surface proteome. Members include receptor tyrosine kinases, phosphatases, co-stimulatory or co-inhibitory immune receptors, growth factor and adhesion receptors, among many others, and are present in most, if not all, cell types.

2006年1月27日 · The immunoglobulin superfamily (IgSF) consists of a group of proteins that exploit the structural robustness and fundamental stability of the immunoglobulin fold for a wide assortment of functions across a broad span of evolutionary time, extending from microorganisms to …

The immunoglobulin superfamily (IgSF) is a superfamily of proteins that share domain structural characteristics: a protein belongs to the immunoglobulin superfamily (IgSF) if it has at least one variable (V) domain or one constant (C) domain (Lefranc et al. 2003, 2005a).