胰岛素样生长因子（insulin like growth factor，IGF）是一组具有促生长作用的多肽类物质，其分泌细胞广泛分布在人体肝、肾、肺、心、脑和肠等组织中。 IGF族有IGF-Ⅰ和IGF-Ⅱ两种。 IGF …

2022年6月1日 · 根据以往研究，IGF1R是一种跨膜酪氨酸蛋白激酶受体，其配体是相对广谱的，insulin、IGF-1和IGF-2均可结合IGF1R，激活其下游信号传导。与IGF-1相比，IGF-2与IR-A …

Insulin-like growth factor 2 (IGF-2, at times IGF-II) is thought to be a primary growth factor required for early development while IGF-1 expression is required for achieving maximal …

Similarly to IGF-1, IGF-2 is mainly produced in the liver and after it is released into circulation, it stimulates growth and cell proliferation. IGF-2 is thought to be a fetal growth factor, as it is …

Insulin-like growth factor 2 (IGF-2) is one of three protein hormones that share structural similarity to insulin. The MeSH definition reads: "A well-characterized neutral peptide believed to be …

Insulin-like growth factor-2 (IGF-2) is a protein closely related to IGF-1 and capable of binding to the IGF-1R as well as its own IGF-2 receptor (IGF-2R). However, whilst the IGF-1R is capable …

The insulin-like growth factor family of ligands (IGF-I, IGF-II, and insulin), receptors (IGF-IR, M6P/IGF-IIR, and insulin receptor [IR]), and IGF-binding proteins (IGFBP-1-6) play critical …

2017年4月9日 · Insulin-like growth factor-1 (IGF-1) and IGF-2 are circulating peptide growth factor hormones important in normal growth and development. Their biological effects are mediated …

IGF-II is unique in that it can activate both IGF-1R and IR-A to promote cell growth and survival. However, of the three ligands, the molecular mechanisms underlying IGF-II action are the …

IGF有 IGF-1 和 IGF-2 两种，IGF-2主要对胎儿生长起作用，而儿童及成人体内起主要作用的、也是我们平常关注多的是IGF-1，IGF-1的产生依赖于 生长激素 水平，是生长激素刺激机体生长和 …