NCB: 一种新的m6A阅读器！可促进mRNA翻译和稳定性 - 知乎
近日，中山大学杨建华教授团队、辛辛那提大学陈建军教授以及芝加哥大学何川教授团队等合作，发现IGF2BP蛋白 (胰岛素样生长因子2 mRNA 结合蛋白) 是一种独特的m6A阅读器，它不 …
Recognition of RNA N6-methyladenosine by IGF2BP proteins
2018年2月23日 · Here, we report the insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs; including IGF2BP1/2/3) as a distinct family of m 6 A readers that target thousands …
IGF2BP3 promotes mRNA degradation through internal m - Nature
2024年8月28日 · Here, we identify that IGF2BP family proteins IGF2BP1-3 can preferentially bind internal mRNA m 7 G. Such interactions, especially IGF2BP3 with m 7 G, could promote the …
IGF2BP1 Gene - GeneCards | IF2B1 Protein | IF2B1 Antibody
2024年12月25日 · IGF2BP1 (Insulin Like Growth Factor 2 MRNA Binding Protein 1) is a Protein Coding gene. Diseases associated with IGF2BP1 include Spermatogenic Failure 19 and …
RNA m6A阅读蛋白IGF2BP增强mRNA稳定性&促进翻译 - 搜狐
2019年11月14日 · 在本研究中，作者鉴定出IGF2BP蛋白（包含IGF2BP1/2/3）是一种新的m6A阅读蛋白，它可识别mRNA上保守的GG (m6A)C序列。 与YTHDF2介导mRNA降解的功能不 …
Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs ... - PubMed
In this review, we discuss the IGF2BP family's role in cancer biology and how this correlates with their proposed functions during embryogenesis. IGF2BPs are mainly expressed in the embryo, …
The IGF2BP family of RNA binding proteins links …
2022年11月1日 · The family of IGF2BP proteins recognize mRNAs modified by methylation and lengthen their lifecycle in the context of stable ribonucleoprotein particles to promote cancer …
Targeting insulin-like growth factor 2 mRNA-binding proteins …
2024年3月15日 · IGF2BP1, the most extensively studied and well-defined member of the IGF2BP family, provides an example for introducing the key RNA binding sites. The KH3-4 domains of …
揭秘 IGF2BP 家族：肿瘤诊疗的新希望 - 生物通
6 小时之前 · 在肿瘤研究的领域中，如同神秘的未知海域，隐藏着许多亟待探索的奥秘。近年来，m 6 a 修饰（一种在 rna 分子上的甲基化修饰，对基因表达调控起着关键作用）在肿瘤的发生 …
IGF2BP family of RNA-binding proteins regulate innate and …
2023年7月12日 · Insulin-like growth factor 2 mRNA-binding proteins (IGF2BP1, IGF2BP2, and IGF2BP3) are a family of RNA-binding proteins that play an essential role in the development …
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