The insulin-like growth factor-binding protein (IGFBP) serves as a transport protein for insulin-like growth factor 1 (IGF-1). [2] Approximately 98% of IGF-1 is always bound to one of six binding proteins (IGF-BP). IGFBP-3, the most abundant protein, accounts for 80% of all IGF binding. IGF-1 binds to IGFBP-3 in a 1:1 molar ratio.

This gene is a member of the Insulin-like growth factor-binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a type-I thyroglobulin domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma.

Die IGfB wurde auf Initiative von Jesper Juul von Robin Menges gegründet und über die Jahre von unterschiedlichen Menschen mitgeprägt und mitgestaltet. Die Abkürzung IGfB steht für „ Internationale Gesellschaft für Beziehungskompetenz in Familie und Organisation “.

As a possible adjunct to insulin-like growth factor 1 and growth hormone in the diagnosis and follow-up of acromegaly and gigantism. Insulin-like growth factor-binding protein 3 (IGFBP-3) is a 264-amino acid peptide (molecular weight 29 kDa) produced by the liver.

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Over the last decade, the concept of an IGFBP family has been well accepted, based on structural similarities and on functional abilities to bind IGFs with high affinities. The existence of other potential IGFBPs was left open.

Location of IGFBPs. TRANSCRIPTIONAL REGULATION OF IGFBPs. Although IGFBPs are secreted into the blood and the physiological function of IGFBPs has been studied and is achieved via IGF-1 and II binding, this review focuses on IGFBP gene expression regulated by transcription factors to help achieve metabolic homeostasis.