IGFBP-3在脂筏中与 EGFR 相互作用，并在DNA损伤刺激下转移到细胞核，在那里两种蛋白与DNA-PK复合以促进非同源末端连接。 IGFBP-3也可能通过与IGFBP-3R（受体）结合来激活下游的各种信号分子诱导细胞凋亡，或者与 TGF-β受体 结合导致 Smad激活 从而导致细胞凋亡。 IGFBP3还可激活 Stat-1 或与RXR-α结合，诱导其抗增殖和促凋亡作用（图1）。 图1. IGFBP-3激活的关键候选分子. 流行病学研究清楚地表明，IGFBP-3水平与癌症的发生呈负相关。 血 …

Insulin-like growth factor-binding protein 3, also known as IGFBP-3, is a protein that in humans is encoded by the IGFBP3 gene. IGFBP-3 is one of six IGF binding proteins (IGFBP-1 to IGFBP-6) that have highly conserved structures and bind the insulin-like growth factors IGF-1 and IGF-2 with high affinity.

2024年12月25日 · IGFBP3 (Insulin Like Growth Factor Binding Protein 3) is a Protein Coding gene. Diseases associated with IGFBP3 include Insulin-Like Growth Factor I and Laron Syndrome . Among its related pathways are Gene expression (Transcription) and Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding ...

igfbp3 作为i型糖尿病（ t1dm ）的生物标志物已被广泛研究。在t1dm患者中，不同人群血清的igfbp3水平明显下降。igfbp3与hba1c、总胆固醇和低密度脂蛋白胆固醇水平相关，与血压成反比，因此也可作为t1dm严重性标志物。

2020年5月5日 · Insulin-like growth factor (IGF) binding protein-3 (IGFBP-3), one of the six members of the IGFBP family, is a key protein in the IGF pathway. IGFBP-3 can function in an IGF-dependent as well as in an IGF-independent manner.

2020年11月25日 · IGFBP-3在脂筏中与EGFR相互作用，并在DNA损伤刺激下转移到细胞核，在那里两种蛋白与DNA-PK复合以促进非同源末端连接。 IGFBP-3也可能通过与IGFBP-3R（受体）结合来激活下游的各种信号分子诱导细胞凋亡，或者与TGF-β受体结合导致Smad激活从而导致细胞凋亡。 IGFBP3还可激活Stat-1或与RXR-α结合，诱导其抗增殖和促凋亡作用（图1）。 图1. IGFBP-3激活的关键候选分子. 流行病学研究清楚地表明，IGFBP-3水平与癌症的发生呈负相关 …

2022年7月7日 · RNA-sequencing analysis indicated that IGFBP-3 is associated with cell migration and cell growth. In fact, IGFBP-3 knockdown downregulates cell migration and causes cells to arrest in G 1. This...

A high IGFI:IGFBP3 ratio was associated with increased benign prostate hyperplasia risk, and high serum IGFBP3 was associated with decreased BPH risk among men with severe symptoms. None of the components in the IGF-1 pathway including IGFBP3, PI3k, and PTEN influence the relation between IRS-1 genotype and prostate cancer risk.

igfbp3. 转运循环中90%的igf。可能封存igf，导致细胞凋亡。也可能直接与细胞表面受体结合，导致基因表达的改变和对igf细胞受体亲和力的改变。功能因环境（即igf水平或可用的细胞受体和目标）而改变。 胎盘、在血液中被大量发现. igfbp4

This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II.