Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that are activated by the neurotransmitter glutamate. [1] .

2002年2月1日 · New insights into the structures of glutamate receptor ion channels (iGluRs), combined with functional and biochemical data, can help us to understand how agonist binding triggers...

一、离子型谷氨酸受体（iGluR） 离子型谷氨酸受体是由多亚基组成的膜受体离子通道复合物，主要见于可兴奋细胞间的突触信号传递。 NMDA受体活化后，藕联G蛋白与磷脂酶C相结合，通过蛋白激酶C磷酸化与Ca2+动员，启动下游一系列生化反应，参与了LTP的发生及其 ...

iGluR (ionotropic glutamate receptor) is a ligand-gated ion channel that is activated by the neurotransmitter glutamate. iGluR are integral membrane proteins compose of four large subunits that form a central ion channel pore. Sequence similarity among all known glutamate receptor subunits, including the AMPA, kainate, NMDA, and δ receptors.

iGluR（离子型谷氨酸受体）是一种配体门控离子通道，由神经递质谷氨酸激活。 iGluR是一种完整的膜蛋白，由四个大亚基组成，形成一个中央离子通道孔。

位于这些突触中的谷氨酸受体离子通道 (iGluR) 是大脑快速信号传导的基石。 它们将突触末端释放的谷氨酸转化为宿主神经元的去极化。 某些 iGluR 参与活动依赖性可塑性，被认为是学习和记忆的基础。 iGluRs 遍布整个神经系统，表明谷氨酸能系统与多种神经和发育障碍有关。 神经元对兴奋性氨基酸及其衍生物的不同反应表明，大脑中应该存在这些物质的多种受体 。 这一假设得到了分子克隆的证实 ，该克隆描绘了 iGluRs 的 AMPA、NMDA、KA和 delta 亚型。 一个独立的代 …

2021年1月14日 · Here, we show that iGluRs, GluR1 and GluR2, are acetylated by acetyltransferase CREB-binding protein upon glutamate stimulation of cells, and are targeted by lysyl oxidase-like 2 for deacetylation....

Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the mammalian central nervous system, are mediated via signaling by ionotropic glutamate receptors (iGluRs). These ligand-gated ion channels are critical to brain function and are centrally implicated in numerous psych …

2017年3月1日 · Here we have compiled the published expression of iGluR subunits in the areas and cell types of developing and adult cortex of rat, mouse, carnivore, bovine, monkey, and human as determined with antibody- and mRNA-based techniques. iGluRs are differentially expressed in the cortical areas and in the species, and all have a unique developmental ...

Ionotropic glutamate receptors (iGluRs) transduce signals derived from release of the excitatory neurotransmitter glutamate from pre-synaptic neurons into excitation of post-synaptic neurons on a millisecond time-scale. In recent years, the elucidation …