IκBα (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor alpha; NFKBIA) is one member of a family of cellular proteins that function to inhibit the NF-κB transcription factor.

2024年12月25日 · This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF …

IKB-α，中文名是人核因子κB抑制蛋白α，是一个生物学名词。 IKB-α的 基因定位 于 14号染色体 长臂1区3 亚区 的2号位上。 Summary:This gene encodes a member of the NF-kappa-B …

A novel mutation in the IKBA gene was discovered in an infant with autosomal-dominant anhidroticectodermal dysplasia with immune deficiency syndrome in glioma cell lines that …

2021年12月1日 · Inflammatory stimuli triggers the degradation of three inhibitory κB (IκB) proteins, allowing for nuclear translocation of nuclear factor-κB (NFκB) for transcriptional induction of its …

The IκBα gene is regulated by NF-κB leading to its resynthesis. De novo synthesized IκBα can associate with free NF-κB sequestering it in the cytoplasm or can enter the nucleus and …

2025年2月20日 · This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF …

2024年12月10日 · This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF …

1995年9月20日 · The human IKBA gene shares similar intron/exon boundaries with the human BCL3 and NFKB2 genes, which is consistent with their conserved Ankyrin repeats. To …

IκB-α is a 37-kDa protein, which is phosphorylated in response to Toll-like receptor, TNF-α, interleukin 1 and other stimulatory signals, and is predominantly able to bind to heterodimers …