IκBα (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor alpha; NFKBIA) is one member of a family of cellular proteins that function to inhibit the NF-κB transcription factor.

2024年12月25日 · This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses.

IKB-α，中文名是人核因子κB抑制蛋白α，是一个生物学名词。 IKB-α的 基因定位 于 14号染色体 长臂1区3 亚区 的2号位上。 Summary:This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses.

A novel mutation in the IKBA gene was discovered in an infant with autosomal-dominant anhidroticectodermal dysplasia with immune deficiency syndrome in glioma cell lines that microRNA-30e* (miR-30e*) directly targets the IkappaBalpha 3'-UTR and suppresses IkappaBalpha expression

2021年12月1日 · Inflammatory stimuli triggers the degradation of three inhibitory κB (IκB) proteins, allowing for nuclear translocation of nuclear factor-κB (NFκB) for transcriptional induction of its target...

The IκBα gene is regulated by NF-κB leading to its resynthesis. De novo synthesized IκBα can associate with free NF-κB sequestering it in the cytoplasm or can enter the nucleus and remove DNA bound NF-κB, thereby establishing an autoregulatory mechanism by …

2025年2月20日 · This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses.

2024年12月10日 · This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses.

1995年9月20日 · The human IKBA gene shares similar intron/exon boundaries with the human BCL3 and NFKB2 genes, which is consistent with their conserved Ankyrin repeats. To examine further the evolutionary relationship between human IkappaBalpha and other members of its gene family, we performed a phylogenetic analysis.

IκB-α is a 37-kDa protein, which is phosphorylated in response to Toll-like receptor, TNF-α, interleukin 1 and other stimulatory signals, and is predominantly able to bind to heterodimers containing p50, p65 and c-Rel. IκB-α is the product of the NFΚBIA gene at chromosome 14 .