补体系统是一种强大的先天免疫系统，可对病原体和癌细胞做出立即反应。 补体因子 H (CFH) 是参与补体级联的调节因子之一，可以中断靶细胞的死亡。

2025年1月1日 · In this study, we identified Complement Factor H (CFH) as a critical regulator in the pathogenesis of IPF, contributing to fibrotic progression through autocrine regulation of complement component C3 and suppression of macrophage phagocytosis.

Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive interstitial lung disease with limited therapeutic options. In this study, we identified Complement Factor H (CFH) as a critical regulator in the pathogenesis of IPF, contributing to …

Results: It was found that CFH promoted lung adenocarcinoma growth in vivo, and CFHconditional medium treatment significantly increased the viability and migration area of A549 cells. CFH-conditional medium increased the phosphorylation of JAK2 and STAT3 in A549 cells.

2012年8月10日 · 生物通报道 近日来自四川大学、加州大学等处的研究人员发表了题为“Complement factor H genotype impact risk of age-related macular degeneration by interaction with oxidized phospholipids”的研究论文，揭示了补体因子H (CFH)基因型影响年龄相关性黄斑变性（AMD）的风险的分子作用机制。

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We perform a study to investigate the CFH /CFHRs gene variants and their roles in IgAN with microangiopathy based on a previous genome-wide association study (GWAS). Methods: We …

补体因子H（CFH）基因家族的结构变异和单核苷酸变异是几种复杂的遗传疾病的基础，包括年龄相关性黄斑变性（AMD）和非典型溶血性尿毒症综合征（AHUS）。

年龄相关性黄斑变性 (age－related macular degeneration，AMD)是一种与年龄、环境、基因相关的多因素退行性眼底病。 补体因子H (complement factor H，CFH)是补体系统中重要的免疫抑制因子，其基因突变可导致CFH的免疫抑制作用减弱，在AMD发病中起一定的作用。

补体因子H缺乏症，又称因子H缺乏症，与补体因子I缺乏症和C3肾病3有关。 与补体因子H缺乏症相关的重要基因是CFH（补体因子H）。 附属组织包括肾脏和肝脏，相关表型为血尿和慢性肾病。