IKK是一种常见的 转录因子 激活蛋白 [1]，可以被位于 细胞质膜 的 TNF -TNFR复合体、 IL -ILR复合体、活化的 Toll样受体 、 病毒感染 和胞外电离辐射激活。 常见的 炎症因子 (包括IL-α和TNF-α等)都可以参与激活IKK。 NF-κB 由两类 亚基 形成的 异源二聚体，一类亚基包括p65，另一类亚基为p50。 NF-κB未被激活时和 IκB -α形成一个复合物，分布在细胞浆中。 在炎症因子、 生长因子 或 趋化因子 等可以激活IKK的情况下，IκBkinase (IKK)复合物会被NF-κB-inducingkinase磷酸 …

In enzymology, an IκB kinase (EC 2.7.11.10) is an enzyme that catalyzes the chemical reaction: Thus, the two substrates of this enzyme are ATP and IκB protein, whereas its two products are ADP and IκB phosphoprotein.

IKK-β is an enzyme that serves as a protein subunit of IκB kinase, which is a component of the cytokine -activated intracellular signaling pathway involved in triggering immune responses. IKK's activity causes activation of a transcription factor known as Nuclear Transcription factor kappa-B …

Inhibitory kappa B kinase beta (IKKβ), known as IKK2, is a key regulatory kinase responsible for the activation of NF-κB through its phosphorylation at Ser177 and Ser181 to promote the phosphorylation of inhibitors of kappa B (IκBs), triggering their ubiquitination and degradation to active the nuclear factor kappa-B (NF-κB) cascade.

The IKK kinase complex is the core element of the NF-κB cascade. It is essentially made of two kinases (IKKα and IKKβ) and a regulatory subunit, NEMO/IKKγ. Additional components may exist, transiently or permanently, but their characterization is still unsure.

2006年10月17日 · IKKbeta (and IKKgamma) are essential for rapid NF-kappaB activation by proinflammatory signaling cascades, such as those triggered by tumor necrosis factor alpha (TNFalpha) or lipopolysaccharide (LPS).

IκB 激酶（IκB kinase;IKK）是一个生物化学与分子生物学名词。 一种丝氨酸特异的蛋白激酶，由多组分构成。 可被细胞外刺激激活、催化IκB (NF-κB的抑制蛋白)特异位点的磷酸化，导致IκB泛素化而被26S蛋白酶体降解，从而破坏IκB与NF-κB复合体，所释放的NF-κB进入细胞核，启动受其调节的基因转录。 IκB 激酶（IκB kinase;IKK）是一个生物化学与分子生物学名词。

The inhibitor of nuclear factor-κB (IκB) kinase (IKK) complex is the master regulator of the NF-κB signaling pathway. The activation of the IKK complex is a tightly regulated, highly stimulus-specific, and target-specific event that is essential for the plethora of functions attributed to NF-κB.

2018年1月1日 · IKK (IκB kinase) is the central regulator of the NF-κB signaling pathway, which plays a key role in immunity, inflammation, and cell survival (Karin and Ben-Neriah 2000; Hayden and Ghosh 2012). NF-κB is the generic name of a family of inducible dimeric transcription factors that are sequestered in the cytoplasm of resting cells by ...

Present at the end of both pathways are the proteins NF-κB, IκB, and the IκB kinase (IKK). These proteins work together to deliver the myriad outcomes that influence context-dependent transcriptional control in immune cells.