KSHV hijacks the antiviral kinase IKKε to initiate lytic replication
2025年1月17日 · Mechanistically, during KSHV lytic replication, IKKε undergoes significant SUMOylation at both Lys321 and Lys549 by the viral SUMO E3 ligase ORF45. This …
Annexin-A1 SUMOylation regulates microglial polarization
2021年1月20日 · Mechanistically, SUMOylated ANXA1 suppressed nuclear factor κB activation and the production of proinflammatory mediators. Further study revealed that SUMOylated …
Sequential Modification of NEMO/IKKγ by SUMO-1 and
2003年11月26日 · Here, we show that genotoxic stress causes nuclear localization of IKK-unbound NEMO via site-specific SUMO-1 attachment. Surprisingly, this sumoylation step is …
(PDF) SUMOylation-Dependent Localization of IKKɛ in PML
2010年2月1日 · SUMO modification of IKKepsilon is required to trigger phosphorylation of nuclear substrates including NF-kappaB p65, thereby contributing to the antiapoptotic function of NF …
Here, we show that genotoxic stress causes nuclear localization of IKK-unbound NEMO via site-specific SUMO-1 attachment. Surpris-ingly, this sumoylation step is ATM-independent, but …
Regulation and Function of IKK and IKK-Related Kinases
Most of the IKKα and IKKβ molecules in the cell are part of IKK complexes that also contain a regulatory subunit called IKKγ or NEMO. Despite extensive sequence similarity, IKKα and …
IKKɛ在PML核体中的SUMOylation依赖性定位对于防止 ... - X-MOL
需要对IKKɛ进行SUMO修饰以触发包括NF-κBp65在内的核底物的磷酸化，从而有助于其抗凋亡功能NF-κB响应DNA损伤。 IKK相关激酶IKK1有助于抗病毒反应，并可以作为癌基因，在乳腺癌 …
NF-κB Induction of the SUMO Protease SENP2: A Negative
SENP2 null cells display biphasic NEMO SUMOylation and activation of IKK and NF-κB, and higher resistance to DNA damage-induced cell death. Our study establishes a self-attenuating …
Expanding NFκB and SUMO ties - PMC - National Center for …
2011年12月1日 · (A) NFκB activation by genotoxic stress involves SUMoylation of NEMO via PIASy (E3) and Ubc9 (E2), which leads to IKK activation. NFκB then activates the synthesis of …
Sequential modification of NEMO/IKKgamma by SUMO-1 and …
2003年12月4日 · The transcription factor NF-kappaB is critical for setting the cellular sensitivities to apoptotic stimuli, including DNA damaging anticancer agents. Central to NF-kappaB …