The interleukin 4 (IL4, IL-4) is a cytokine that induces differentiation of naive helper T cells (T h 0 cells) to T h 2 cells. Upon activation by IL-4, T h 2 cells subsequently produce additional IL-4 in a positive feedback loop. IL-4 is produced primarily by mast cells, T …

白细胞介素 （IL-4）是一个为人熟知的细胞因子。 从它被发现开始，它就与 CD4 阳性 的 Th细胞 、以及 脾脏 、 淋巴结滤泡T细胞 的活化紧密地联合在了一起。 同时，它也参与了 B细胞 的活化、抗体的生成、 MHC 分子 及 FC受体 的表达。 总的来说，它是介导 2 型免疫反应 的重要细胞因子，在多种免疫细胞的功能调节上起着重要的作用。 IL-4 一般特性. 白细胞介素 4（IL-4）是主要由活化的 T 淋巴细胞、肥大细胞、嗜碱性粒细胞产生的一种多效性细胞因子。 1982 年 Howard 发 …

2002年11月11日 · Interleukin-4 (IL-4) and IL-13 are the only cytokines known to bind to the receptor chain IL-4Rα. Receptor sharing by these two cytokines is the molecular basis for their overlapping biological functions.

Interleukin-4 (IL-4) is a four-α-helical bundle type I cytokine with broad pleiotropic actions on multiple lineages. Major actions of IL-4 were initially discovered for B and T cells, but this cytokine acts on more than a dozen different target ...

IL-4促进B细胞MHCⅡ类抗原、 FcεRⅡ/CD23 和 CD40 的表达，并增强B细胞提呈抗原能力，使免疫系统对小量抗原刺激发生免疫应答。 增加FcεRⅡ/CD23 (IgE Fc 段低亲和力受体) 的表达，并释放可溶性CD23 (sCD23)/IgE结合因子 (IgE-BF)，与mIgE阳性细胞结合并诱导其分化，可能与促进B细胞IgE的产生有关。 IL-4提高 LPS 刺激小鼠B细胞 IgG1、IgE产生水平分别为8～10倍和10～100倍，但对IgG3分泌降低6～10倍，IgG2a、IgG2b和IgM有不同程度下降，对IgA产生 …

2016年12月1日 · Interleukin-4 is the prime anti-inflammatory cytokine involved in cell proliferation, gene expression and apoptosis. α chain of IL-4R is also a fundamental part of IL-13R hence, signifying its role in both IL-4 and IL-13 signaling pathway.

In this review, recent advances in understanding these three IL-4-related branch points—alternative splicing of IL-4, differential receptor engagement by IL-4, and differential regulation of macrophage activation by IL-4—are summarized in light of …

Upon binding to IL4, IL4R receptor dimerizes either with the common IL2R gamma chain/IL2RG to produce the type 1 signaling complex, located mainly on hematopoietic cells, or with the IL13RA1 to produce the type 2 complex, which is expressed also on nonhematopoietic cells (PubMed: 10219247, PubMed: 11526337, PubMed: 18243101).

Interleukin-4 (IL-4), a multifunctional cytokine, is an important regulator of inflammation. When deregulated, IL-4 activity is associated with asthma, allergic inflammation, and multiple types of cancer, making it a potentially impactful target for therapies in a variety of illnesses.

2023年2月1日 · IL-4 (right panel) acts neuroprotectively, reducing lesion volume, neurodegeneration, astrogliosis and demyelination. In IL-4-treated mice, M2-like microglia are induced and anti-inflammatory cytokines, as well as growth factors (see Section 6) are increased, leading to neuroprotection and remyelination.