Apoptotic activity of IL-25 was mediated by differential expression of its receptor, IL-25R, which was expressed in high amounts in tumors from patients with poor prognoses but was low in nonmalignant breast tissue. In response to IL-25, the IL-25R on the surface of breast cancer cells activated caspase-mediated apoptosis.

2022年12月16日 · IL-25受体是一个由IL-17RB/IL-17RA组成的异源二聚体，激活后介导炎症、凋亡等多种信号。 IL-25促进肿瘤进展. 化疗耐药. 肺癌等癌细胞表达IL-25，通过诱导NF-κB活化，上调MVP（Major vault protein），产生对于顺铂化疗的抵抗。 肿瘤干细胞干性

2011年4月13日 · Apoptotic activity of IL-25 was mediated by differential expression of its receptor, IL-25R, which was expressed in high amounts in tumors from patients with poor prognoses but was low in nonmalignant breast tissue. In response to IL-25, the IL-25R on the surface of breast cancer cells activated caspase-mediated apoptosis.

Interleukin 25 (IL-25) is a major 'alarmin' cytokine, capable of initiating and amplifying the type immune response to helminth parasites. However, its role in the later effector phase of clearing chronic infection remains unclear.

Interleukin 25 (IL-25), also known as IL-17E, is a member of the IL-17 cytokine family and an important regulator of the type 2 immune response. Accumulating evidence suggests that IL-25 interacts with diverse immune as well as non-immune cells and ...

2024年12月25日 · IL25 (Interleukin 25) is a Protein Coding gene. Diseases associated with IL25 include Psoriasis 8 and Inflammatory Bowel Disease 29. Among its related pathways are IL-17 Family Signaling Pathways and Cytokine Signaling in Immune system.

2018年9月21日 · Interleukin 25 (IL-25) is a major 'alarmin' cytokine, capable of initiating and amplifying the type immune response to helminth parasites. However, its role in the later effector phase of clearing chronic infection remains unclear.

IL-25R is a 55 kDa transmembrane protein that dimerizes with IL-17RA to form the functional receptor for IL-25 (IL-17E). IL-25R is detectable in various tissues, including the lung and gastrointestinal tract and exists as both membrane bound and soluble form. IL-25/IL-25R interaction has been shown to activate the NF-kB, MAPK, and JNK pathways ...

[Figure: see text] Interleukin 25 (IL-25) is a ligand for IL-25 receptor (IL-25R) with apoptotic effect on breast cancer epithelial cells that are produced by peripheral blood mononuclear cells (PBMCs). In this study, we aimed to evaluate IL-25/IL-25R mRNA expression in …

2023年11月1日 · 研究发现，肠道il-25激活的ilc2s创造了一个固有的癌症允许微环境。结肠癌患者具有更高的肿瘤il25表达，与减少的生存率和增加的il-25r表达的肿瘤驻留ilc2s以及与受损的抗肿瘤反应相关的髓源性抑制细胞 (mdscs) 相关。