IL-26 is a natural human antimicrobial that promotes immune sensing of bacterial and host cell death. IL-26 is a cationic amphipathic protein that kills extracellular bacteria via membrane-pore formation. Furthermore, Th17 cell–derived IL

白细胞介素 26（IL-26），原命名为 AK155，是在 2000 年由 Knappe 等人在研究单纯疱疹病毒（HSV）的转化 T 细胞时，从基因文库中筛选到的一个新 cDNA（AK155）。 由于其氨基酸序列以及受体结构与 IL-10 家族成员具有一定的相似性，后成为了 IL-10 细胞因子家族的成员，并被命名为 IL-26。 IL-26 是一个分子量为 19kDa，含有 171 个氨基酸的蛋白质，其氨基酸序列与白细胞介素 10 相似，它由一个信号序列，6 个螺旋和 4 个保守的半胱氨酸残基组成。 这 4 个保守的半 …

2019年2月11日 · Interleukin 26 (IL-26) is the most recently identified member of the IL-20 cytokine subfamily, and is a novel mediator of inflammation overexpressed in activated or transformed T cells. Novel properties have recently been assigned to IL-26, owing to its non-conventional cationic, and amphipathic features.

2015年7月21日 · IL-26 is a 171-amino acid protein that belongs to the IL-10 family of cytokines, a family that includes IL-10, IL-19, IL-20, IL-22 and IL-24 . The IL-26 protein is encoded by the IL26 gene located on chromosome 12q15 between genes for interferon (IFN)-γ and IL-22 [ 6 , 7 ], and is conserved in several vertebrate species but not in mice and ...

2016年6月23日 · In this context, IL-26, an emerging member of IL-10 family cytokines, stands distinct as it exerts antimicrobial response not only by priming various innate immune cells and modulating antiviral responses but also by eliciting direct microbicidal action through affecting the formation of membrane pores.

2024年12月25日 · IL26 (Interleukin 26) is a Protein Coding gene. Diseases associated with IL26 include Crohn's Disease and Hidradenitis Suppurativa. Among its related pathways are MIF Mediated Glucocorticoid Regulation and TGF-Beta Pathway. Gene Ontology (GO) annotations related to this gene include cytokine activity. An important paralog of this gene is IL10.

Upon binding to its receptor complex (IL-10R1/IL-20R2), IL-26 activates multiple signalling mediators, especially STAT1/STAT3. In cancer, IL-26 induces IL-22-producing cells, which consequently decrease cytotoxic T-cell functions and promote tumour growth through activating anti-apoptotic proteins.

2021年10月30日 · IL-26 is referred to as an identified member of the IL-10 family and IL-20 subfamily. Due to having a unique cationic structure, IL-26 exerts diverse functions in several diseases. Since IL-26 is mainly secreted from Th17, it is …

The production of interleukin (IL)-26 was initially attributed to T cells, and in particular to Th17 cells. However, more recent findings indicate IL-26 production in natural killer (NK) cells, macrophages and fibroblast-like cells as well.

As such, IL-26 is a potential therapeutic target to augment host immune responses against microbial pathogens but also to prevent inflammation and tissue damage in a variety of autoimmune diseases. Keywords: Antimicrobial; Autoimmunity; IL-26; Skin inflammation; Th17.