2021年6月16日 · 肿瘤微环境中的il-30/il-27p28作用. 上图很清晰的标识了il-30上调细胞因子（il-1β，il-6，il-8等），趋化因子（cxcl1/2/10等），免疫检查点（pd-l1)，下调抑癌基因（pten等）。

Interleukin 30 (IL-30) forms one chain of the heterodimeric cytokine called interleukin 27 (IL-27), thus it is also called IL27-p28. IL-27 is composed of α chain p28 and β chain Epstain-Barr induce gene-3 (EBI3).

2021年5月28日 · IL-30, also known as IL-27p28 or IL-27A, was discovered in a search for novel helical cytokines 5. It forms a noncovalent bond with the Ebi3 subunit, which also associates with the IL-12p35...

2019年9月30日 · As an independent cytokine, IL-30 can inhibit gp130 signaling in murine cells giving it the potential to negate the anti-tumor effects that IL-27 provides. The mechanisms involved in IL-30 production and its ability to function independently still …

There is a need to better understand how cytokines like IL-27, IL-30, and IL-35 interact with one another, and how a developing tumor can exploit these interactions to enhance immune suppression. Current cytokine-based immunotherapies are associated with cytotoxic side effects which limits the success of treatment.

2019年10月1日 · There is a need to better understand how cytokines like IL-27, IL-30, and IL-35 interact with one another, and how a developing tumor can exploit these interactions to enhance immune suppression. Current cytokine-based immunotherapies are associated with cytotoxic side effects which limits the success of treatment.

IL-30, the p28 subunit that forms IL-27 together with Ebi3 and is also known as IL-27p28 or IL-27A, has been considered a surrogate to represent IL-27. However, it was later discovered that IL-30 can form complexes with other protein subunits, potentially leading to overlapping or discrete functions.

IL-30 是与 Ebi3 一起形成 IL-27 的 p28 亚基，也称为 IL-27p28 或 IL-27A，被认为是代表 IL-27 的替代物。 然而，后来发现 IL-30 可以与其他蛋白质亚基形成复合物，可能导致功能重叠或离散。

IL-30, also known as IL-27p28 or IL-27A, was discovered in a search for novel helical cytokines 5. It forms a noncovalent bond with the Ebi3 subunit, which also associates with the IL-12p35 subunit to form IL-35 6. The IL-30/Ebi3 complex, named IL-27, exhibits anti-inflammatory (and regulatory) functions.

2021年5月1日 · IL-30 forms the IL-27 complex with the Ebi3 protein and was thought to be a surrogate for IL-27 in terms of activity. However, recent insights suggest that IL-30 may perform discrete immune...