Interleukin-31 (IL-31) is a protein that in humans is encoded by the IL31 gene that resides on chromosome 12. [ 5 ] [ 6 ] [ 7 ] IL-31 is an inflammatory cytokine that helps trigger cell-mediated immunity against pathogens.

2024年12月25日 · IL31 (Interleukin 31) is a Protein Coding gene. Diseases associated with IL31 include Allergic Contact Dermatitis and Contact Dermatitis. Among its related pathways are Cytokine Signaling in Immune system and Interleukin-6 family signaling. Gene Ontology (GO) annotations related to this gene include cytokine activity.

IL-31 is a critical cytokine involved in neuroimmune communication, which opens new avenues for cytokine modulation in neuroinflammatory diseases including AD/pruritus, as validated by recent clinical trials using an anti-IL-31 antibody.

IL-31 acts on a broad range of immune- and non-immune cells and therefore possesses potential pleiotropic physiological functions, including regulating hematopoiesis and immune response, causing inflammatory bowel disease, airway hypersensitivity and dermatitis.

2022年6月10日 · The results showed that IL-31 plays a crucial role in the pathogenesis of systemic skin manifestations, prognosis, and itch severity. Traditional therapies target this interleukin indirectly, but monoclonal antibodies (Mab) directed against it have shown efficacy and safety profiles comparable with biological drugs that are already available.

2012年6月1日 · Interleukin-31 (IL-31) was recently discovered as a new member of the IL-6 family of cytokines. IL-31 signals through a heterodimeric receptor composed of OSMR and IL-31RA, a complex that stimulates the JAK-STAT, the RAS/ERK …

IL-31 targeting has proven to be a safe and convenient method to treat itching, and it also has shown some potential in treating oncological diseases and a plethora of inflammatory conditions that could lead to organ failures, such as hepatitis and sepsis.

Interleukin-31 (IL-31) was recently discovered as a new member of the IL-6 family of cytokines. IL-31 signals through a heterodimeric receptor composed of OSMR and IL-31RA, a complex that stimulates the JAK-STAT, the RAS/ERK and the PI3K/AKT signal transduction pathways.

IL-31 signals through a receptor complex consisting of IL-31 receptor α and oncostatin M receptor β. The available data show that IL-31 is strongly linked with chronic pruritic skin disorders, such as atopic eczema, and represents a novel target for directed drug therapy.

IL-31 is a novel cytokine expressed in many human tissues and involved mainly in T H 2-weighted inflammation. IL-31 signals through a receptor complex consisting of IL-31 receptor α and oncostatin M receptor β. The available data show that IL …