白细胞介素-36 (IL-36) - 丁香通
2017年9月12日 · IL-36（白细胞介素-36）是新的促炎细胞因子。 可由单核细胞、T 淋巴细胞、角质细胞等多种细胞产生。 结构：由 3 个生物学功能相似的分子 IL-36α、IL-36β、IL-36γ组成， …
炎症性疾病治疗药物潜力靶点IL-36 - 知乎 - 知乎专栏
IL-36通过IL-36R和IL-1受体辅助蛋白（IL-1 receptor accessory protein, IL-1RAcP）介导细胞内信号转导。 在人体内，编码IL-36Ra的基因失活突变会导致IL-36R信号失调，主要表现为弥漫型 …
Interleukin 36 - Wikipedia
Interleukin 36, or IL-36, is a group of cytokines in the IL-1 family with pro-inflammatory effects. The role of IL-36 in inflammatory diseases is under investigation. [1] There are four members …
罕见型银屑病治疗新时代，靶向IL-36R研究已就位 - 知乎
公开资料显示，BI655130是一款“first-in-class”在研新药，可阻断白细胞介素-36受体（IL-36R）的作用，具有治疗皮肤病、 掌跖脓疱病 、溃疡性结肠炎等多种炎症性疾病的潜力，全球范围内 …
Interleukin-36: Structure, Signaling and Function - PubMed
Protease mediated N-terminal processing is needed for cytokine activation. In the skin, the functional role of IL-36 is to contribute to host defense through inflammatory response. …
Function and Regulation of IL-36 Signaling in Inflammatory …
The IL-36 subfamily of cytokines belongs to the IL-1 superfamily and consists of three pro-inflammatory agonists IL-36α, IL-36β, IL-36γ, and an IL-36 receptor (IL-36R) antagonist, IL …
A review of IL-36: an emerging therapeutic target for ... - PubMed
2022年4月26日 · Increasing evidence in the IL-36 pathway demonstrates their potential as a therapeutic target for treating inflammatory skin diseases, such as generalized pustular …
Biology of IL-36 Signaling and Its Role in Systemic Inflammatory ...
Interleukin (IL)-36 signal pathways induce inflammatory responses. Pro-IL-36 cytokines are inactive proteins and require post-translational processing to fully unleash the pro …
IL-36：炎症与肿瘤_细胞因子 - 搜狐
2021年2月4日 · 最近的一项研究使用il-36基因治疗实验性纤维肉瘤，il-36治疗导致显著减少肿瘤生长，表明有抗肿瘤作用。 结肠癌中，高表达IL-36α和IL-36β或IL-36α加上低水平的IL-36γ，表 …
Biology of IL-36 cytokines and their role in disease - PubMed
2013年12月15日 · In this review the discovery and biological function of the cytokines IL-36α, IL-36β, IL-36γ and IL-36Ra will be discussed, and their role in the pathogenesis of a wide variety …
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