Learn how Microsoft meets Department of Defense (DoD) Impact Level 5 (IL5) standards.

Interleukin 5 (IL-5) is an interleukin produced by type-2 T helper cells and mast cells.

2024年4月19日 · DoD Impact Level 5 is designed for unclassified National Security Systems (NSSs) supporting DoD missions. It is intended for systems and data covering Controlled Unclassified Information (CUI) that require a higher level of protection than IL4. This includes higher-sensitivity CUI, Mission-Critical Information, and NSS. Let’s zoom in on that.

IL-5 is an interdigitating homodimeric glycoprotein and a member of the four α helical bundle motifs that are conserved among hematopoietic cytokines. IL-5 exerts its effects on target cells via IL-5R, comprising an IL-5α and βc subunit.

Interleukin 5 (IL-5) plays a critical role in maturation, differentiation, activation and tissue recruitment of eosinophils [36]. Mepolizumab and reslizumab — both humanized anti-IL-5 antibodies — are highly specific anti-eosinophil drugs.

Interleukin-5 (IL-5) exerts a central pathogenic role in differentiation, recruitment, survival, and degranulation of eosinophils. Indeed, during the last years, significant advances have been made in our understanding of the cellular and molecular ...

While interleukin-5 (IL-5) is initially identified by its ability to support the growth and terminal differentiation of mouse B cells in vitro into antibody-secreting cells, recombinant IL-5 exerts pleiotropic activities on various target cells including B cells, eosinophils, and basophils.

IL-5 critically regulates expression of genes involved in proliferation, cell survival and maturation and effector functions of B cells and eosinophils. Thus, IL-5 plays a pivotal role in innate and acquired immune responses and eosinophilia.

Interleukin-5 (IL-5) is a cytokine synthesized and secreted mainly by activated CD4 + helper T cells of the T-helper-2 (Th2) subset, and also by mast cells and eosinophils. The effector functions of human IL-5 (hIL-5) are principally associated with a single cell type, the eosinophil.

2009年10月9日 · IL-5 was originally defined as a T-cell-derived cytokine that triggers activated B cells for terminal differentiation into antibody-secreting plasma cells, at least in mice. Concurrently, IL-5 was recognized as the major maturation and differentiation factor for …