一、il-1家族配体、受体成员白细胞介素-1（il-1）家族细胞因子是先天免疫系统和适应性免疫系统中的关键信号分子，介导对多种刺激的炎症反应。家族配体成员有：il-1α、il-1β、 il-1ra、 il-18、 il-33、il-36α、…

The soluble form is produced by hepatocytes and regulated by pro-inflammatory cytokines (IL1-β and a combination of IL1-β and IL-6) and other acute phase proteins. The intracellular form was found in fibroblasts, monocytes, neutrophils, keratinocytes and bronchial epithelial cells.

il-1β作为一种关键的促炎细胞因子，参与多种自身免疫性炎症反应和多种细胞活动，包括细胞增殖、分化和凋亡。il-1β与il1-α和il18一起，通过多种下游机制协调免疫反应。il-1β参与il-6和tnf-α的调节，还激活血管粘附分子icam1。

白细胞介素1族包括11种细胞因子，它们组成了促炎细胞因子的复杂网络。 这些细胞因子通过调控白细胞和内皮细胞的整合素的表达，启动和控制炎症反应。 [2]由于il-1α和il-1β最先发现而且促炎能力最强，对它们的研究也最多。

最初测定的为 IL1和IL2。IL1属于monokine，以前曾以淋巴细胞活化因子（lymphocyte activating factor）命名。细胞促进 蛋白质 （mitogenic protein）以及B细胞活化因子（B cell－activating factor）等七种名称称之。

白细胞介素 是由多种细胞产生并作用于多种细胞的一类细胞因子，它和血细胞生长因子同属细胞因子。 两者相互协调，相互作用，共同完成造血和免疫调节功能。白细胞介素在传递信息，激活与调节免疫细胞，介导t、 b细胞 活化、增殖与分化及在炎症反应中起重要作用。

Jan 18, 2010 · Interleukin-1 (IL-1), which as its name suggests was the first interleukin to be described, possesses many biological activities. Indeed, before its molecular identification in the mid 1980s, IL-1 ...

Both the TLR and IL-1 families nonspecifically augment antigen recognition and activate lymphocyte function. The lymphocyte-activating function of purified IL-1 was first described in 1979 3 and is now termed a fundamental property of the acquired immune response. IL-1β is the most studied member of the IL-1 family due to its role in mediating autoinflammatory diseases. 4 Unquestionably, IL ...

The interleukin-1 (IL-1) family of cytokines comprises 11 proteins (IL-1F1 to IL-1F11) encoded by 11 distinct genes (IL1A, IL1B, IL1RN, IL18, and IL1F5 to IL1F11 in humans, Il1A to Ilf11 in mice) (1–3).The main function of IL-1–type cytokines is to control proinflammatory reactions in response to tissue injury by pathogen-associated molecular patterns (PAMPs, such as bacterial or viral ...

Over recent years it has become increasingly clear that innate immune responses can shape the adaptive immune response. Among the most potent molecules of the innate immune system are the interleukin-1 (IL-1) family members. These evolutionarily ancient cytokines are made by and act on innate immune …