Interleukin-1 beta (IL-1β) also known as leukocytic pyrogen, leukocytic endogenous mediator, mononuclear cell factor, lymphocyte activating factor and other names, is a cytokine protein that in humans is encoded by the IL1B gene.

2024年12月25日 · IL1B (Interleukin 1 Beta) is a Protein Coding gene. Diseases associated with IL1B include Gastric Cancer and Diffuse Gastric And Lobular Breast Cancer Syndrome. Among its related pathways are MIF Mediated Glucocorticoid Regulation and …

白细胞介素-1β (Interleukin—1β,IL-1β)是一种主要由单核巨噬细胞产生的重要细胞因子和多肽调节因子。 在细胞免疫激活中发挥调节作用。 IL-1β参与机体造血系统、神经、内分泌系统、机体炎症反应和某些抗肿瘤生理过程,IL-1在局部组织内持续地异常合成,可导致机体发热、炎症反应,某些疾病的病理改变。 主要生物特性： 1．IL-1的产生细胞IL-1主要由巨噬细胞产生；此外几乎所有的有核细胞，如B细胞、 NK细胞 、体外培养的 T细胞 、角质细胞、 树突状细胞 、星形细胞、成 …

IL-1β作为一种关键的促炎细胞因子，参与多种自身免疫性炎症反应和多种细胞活动，包括细胞增殖、分化和凋亡。 IL-1β与IL1-α和IL18一起，通过多种下游机制协调免疫反应。 IL-1β参与IL-6和TNF-α的调节，还激活血管粘附分子ICAM1。 IL-1β被认为是典型的多功能细胞因子，几乎影响所有类型的细胞，无论是单独作用还是与其他细胞因子联合使用。 IL-1β对几乎所有组织的细胞防御和组织修复至关重要，与疼痛、炎症和自身免疫有关。 IL-1β也参与神经保护、组织重塑和修复。 IL …

Interleukin-1 beta (IL1B)靶点介绍及实验小贴士靶点介绍助您了解其蛋白功能，蛋白表达，蛋白定位及异构体和翻译后修饰等特质。 同时列举了实用的WB实验小贴士，助您实验成功。

The cytokine interleukin-1β (IL-1β) is a key mediator of the inflammatory response. Essential for the host-response and resistance to pathogens, it also exacerbates damage during chronic disease and acute tissue injury. It is not surprising therefore that there is a huge level of interest in how this protein is produced and exported from cells.

2025年2月20日 · Patients with severe Coronavirus Disease 2019 (COVID-19) present elevated levels of pro-inflammatory cytokines such as IL-1B in bronchial alveolar lavage fluid samples.

2020年7月4日 · The IL1B gene is induced after "priming" of the cells and a second signal is required to allow IL-1β maturation by inflammasome-activated caspase-1. IL-1β is then released and leads to transcription of target genes through its ligation with IL-1R1 on target cells.

2021年3月5日 · IL-1β作为一种关键的促炎细胞因子，参与多种自身免疫性炎症反应和多种细胞活动，包括细胞增殖、分化和凋亡。 IL-1β与IL1-α和IL18一起，通过多种下游机制协调免疫反应。 IL-1β参与IL-6和TNF-α的调节，还激活血管粘附分子ICAM1。 IL-1β被认为是典型的多功能细胞因子，几乎影响所有类型的细胞，无论是单独作用还是与其他细胞因子联合使用。 IL-1β对几乎所有组织的细胞防御和组织修复至关重要，与疼痛、炎症和自身免疫有关。 IL-1β也参与神经保护、 …

IL1B promotes the transendothelial migration of mesenchymal stem cells through CXCR3-CXCL9 axis. Levels of plasma interleukin-1 are elevated in the peripheral blood of patients with Parkinson's disease-related pain.