OriGene Anti-IL1F6 Monoclonal (OTI3A12), TrueMAB™, Catalog # TA501427. Tested in Western Blot (WB) and Immunocytochemistry (ICC/IF) applications. This antibody reacts with Human samples. Supplied as 100 µL purified antibody (0.42 mg/mL).

Interleukin-36 alpha also known as interleukin-1 family member 6 (IL1F6) is a protein that in humans is encoded by the IL36A gene. [5] [6]

Homo sapiens gene IL1F6, encoding interleukin 1 family, member 6 (epsilon). RefSeq annotates one representative transcript. According to AceView, this gene is expressed at low level, only 4.6% of the average gene in this release. The sequence of this gene is defined by 6 GenBank accessions, some from esophagus (seen 2 times).

2021年8月27日 · 人和小鼠的基因组编码四个il-36基因，il1f6（编码il-36a）、il1f8（编码il-36β）、il1f9（编码il-36𝜸）以及il1f5（编码il-36ra），与il-36r受体结合发挥功能。 其中前三个属于激动剂激活MyD88依赖的信号通路，而IL-36Ra竞争性地与IL-36R结合抑制其招募IL-1RAcP受体，阻 …

2017年10月23日 · IL-1 family member 6 (IL-1F6, also known as IL-36α) is overexpressed in injured DTs from various mouse kidney diseases, including lupus nephritis, diabetic nephropathy, and traumatic kidney injury (8 – 10). Therefore, IL-36α could be a useful marker of DT injury; however, its pathological function remains unclear. in vitro.

2018年7月1日 · IL-36α (gene symbol Il1f6), a member of the IL-36 family, is closely associated with inflammatory diseases, including colitis and psoriasis. In this study, we found that Il1f6 -/- mice developed milder psoriasiform dermatitis upon treatment with imiquimod, a ligand for TLR ligand 7 (TLR7) and TLR8, whereas Il1f6 -/- mice showed similar ...

Anti-IL1F6 mouse monoclonal antibody (BD-PE3590) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY IL1F6 . HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY …

2007年4月27日 · Use the links below as well as the links to the gene information pages above to check existing GO annotation for IL1F6. GO annotation for a particular gene in a set of orthologous genes will vary between species depending upon the experimental evidence available, annotation completeness, and fundamental differences in biology.

基因名称: Il1f6: Gene ID: 54448: 品系名称: 遗传背景: C57BL/6J: 修饰方式: KO: 应用领域: 免疫相关研究: 表型: 敲除等位基因纯合子小鼠对咪喹莫德诱导的银屑病样皮炎的敏感性降低，但对葡聚糖硫酸钠诱导的结肠炎的敏感性正常。

IL-36 alpha (IL-1F6) 是 IL-36 家族的其中一个亚型，属于 IL-1 超家族。 IL-36 alpha 介导炎症反应。 IL-36 alpha 与 IL-36R 结合并激活 NF-κB 和 MAPK 信号通路，但这种激活需要中性粒细胞来源的蛋白酶对 IL-36 alpha 的 N 端进行切割。 IL-36 alpha 还可以结合 IL-1Rrp2 并募集 IL-1RAcP。 IL-36 alpha 通过 IL-36R/IL-1RAcP 激活 MAPK、Erk1/2 和 JNK 信号通路。 IL-36 alpha/IL-1F6 蛋白, Human (153a.a) 是一种由 E. coli 产生的重组人 IL-36 alpha (K6-F158)，不带任何标签。