Interleukin 21 receptor is a type I cytokine receptor. IL21R is its human gene. [5] The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21).

IL-21 produced by follicular helper CD4 T cells (T FH) acts directly on B cells via their IL-21 receptors (IL21R) to generate high-affinity, class-switched antibodies [1, 2].

2024年12月25日 · IL21R (Interleukin 21 Receptor) is a Protein Coding gene. Diseases associated with IL21R include Immunodeficiency 56 and Ige Responsiveness, Atopic . Among its related pathways are Cytokine Signaling in Immune system and Th17 Differentiation .

Its private receptor, IL-21R, has been shown to activate the Janus kinase/signal transducers and activators of transcription signaling pathway upon ligand binding. Initial studies have demonstrated that IL-21 has pleiotropic effects on the proliferation, differentiation, and effector functions of B, T, natural killer, and dendritic cells.

Patients with primary immunodeficiency caused by IL21R or IL21 mutations have been described 6– 9, and their phenotypes have provided invaluable insights into the role of IL-21 in host defense.

We demonstrate that IL-21/IL-21R interactions play a critical role in allergic skin inflammation to e.c. introduced antigen by promoting the migration of skin DCs to DLNs and the subsequent elicitation of an immune response. IL-21 and IL-21R protein expression is upregulated in skin lesions of human AD.

2014年4月22日 · Interleukin-21 (IL-21) binding stabilizes the complex between the IL-21 receptor (IL-21R) and the common cytokine-γ chain, γ c, leading to the activation of Janus kinase 1...

2025年2月8日 · parathyroid hormone (PTH) and interleukin 21 receptor (IL21R), achieved consistent association results for bone mineral density in both discovery and replication samples. IL-21R is expressed in follicular lymphoma cells from early diagnosed, untreated patients. It mediates apoptosis.

2024年12月9日 · Title: IL21R hypomethylation as a biomarker for distinguishing benign and malignant breast tumours. Interleukin-21 receptor signaling promotes metabolic dysfunction-associated steatohepatitis-driven hepatocellular carcinoma by inducing immunosuppressive IgA[+] B …

2020年1月1日 · IL-21R deficiency results from deleterious mutations in the IL21R gene, located in chromosome 16p12. IL-21R-deficient patients present with cellular and humoral immunity defects, including variable NK cell dysfunction.