Interleukin 27 receptor, alpha is a subunit of the interleukin-27 receptor. IL27RA is its human gene. [5] In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12.

Mar 30, 2025 · IL27RA (Interleukin 27 Receptor Subunit Alpha) is a Protein Coding gene. Diseases associated with IL27RA include Epilepsy and Autism Spectrum Disorder. Among its related pathways are IL27-mediated signaling events and Interleukin-12 family signaling.

Mar 20, 2024 · Here we report biallelic loss-of-function variants in IL27RA that underlie an acute and severe primary EBV infection with a nevertheless favourable outcome requiring a minimal treatment.

Cytokine receptor IL27RA is an NF-kappaB-responsive gene involved in CD38 upregulation in multiple myeloma. Structural insights into the assembly and activation of the IL-27 signaling complex. IL27 Signaling Serves as an Immunologic Checkpoint for Innate Cytotoxic Cells to Promote Hepatocellular Carcinoma.

Nov 24, 2021 · Mechanistic studies demonstrate that IL-27 directly targets adipocytes, activating p38 MAPK–PGC-1α signalling and stimulating the production of UCP1. Notably, therapeutic administration of...

Nov 23, 2023 · These results identify IL-27 and its specific receptor IL27RA as a critical immune axis for the antiviral immune response and as robust correlates of viral load and proviral reservoir size in mononuclear leukocytes in HIV infection.

Jul 9, 2024 · IL-27 is a well-recognized pleiotropic immune regulator with potent inhibitory effects on type 17 immune responses. However, its actions on γδ T17 mediated inflammation and the underlying...

Jul 9, 2020 · In this study, we show that aging-related inflammation promotes HSC aging through tumor necrosis factor-α (TNF-α)→ERK→ETS1→interleukin27Ra (IL27Ra) pathway. TNF-α, a well-known biomarker of inflammation, increases during aging and induces the expression of IL27Ra on HSCs via ERK-ETS1 signaling.

May 17, 2022 · Interleukin 27 (IL-27) is a heterodimeric cytokine that functions to constrain T cell-mediated inflammation and plays an important role in immune homeostasis.

Jul 27, 2023 · MM cells overexpress NF-ĸB–responsive genes IL27RA and JAM2, providing candidate targets for therapeutic intervention. IL-27Rα-mediated signaling via STATs upregulates CD38, a target of monoclonal antibody–mediated therapy, in MM cells.