Interleukin 28 receptor, alpha subunit is a subunit for the interleukin-28 receptor. IL28RA is its human gene. The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukin 10 receptor, beta (IL10RB).

2024年12月25日 · IFNLR1 (Interferon Lambda Receptor 1) is a Protein Coding gene. Diseases associated with IFNLR1 include Psoriasis 12 and Zika Virus Congenital Syndrome. Among its related pathways are Cytokine Signaling in Immune system and Overview of interferons-mediated signaling pathway.

2025年2月8日 · Downregulated expression of IL28RA is involved in the pathogenesis of pancreatic ductal adenocarcinoma. Interferon III-related IL28RA variant is associated with rheumatoid arthritis and systemic lupus erythematosus and specific disease sub-phenotypes.

Interleukin (IL) 28 receptor α (IL28RA) is a well-known candidate for psoriasis susceptibility based on previous genome-wide association study (GWAS) analysis. However, the function of IL28RA in psoriasis has not been elucidated. In the present study, the expression of IL28RA was significantly decre …

IL28RA is lowly expressed in pancreatic cancer patients, and has certain diagnostic value for early pancreatic cancer. Its up-regulated expression can inhibit the proliferation and invasion of pancreatic cancer cells, and promote their apoptosis by inhibiting the activation of …

2024年12月20日 · Interleukin 28A (IL28A) and interleukin 28B (IL28B) may play a role in immune regulation post-AMI by specifically binding to interleukin 28 receptor alpha (IL28RA). However, the precise...

2024年3月5日 · Downregulated expression of IL‑28RA is involved in the pathogenesis of pancreatic ductal adenocarcinoma. Interferon III-related IL28RA variant is associated with rheumatoid arthritis and systemic lupus erythematosus and specific disease sub-phenotypes.

IFNLR1 (interferon lambda receptor 1, also known as IL28RA) may have an essential role in anti-viral activity and immune regulation, and it has been recently reported that it inhibits human...

IFN-lambda1, -lambda2, and -lambda3 bind to the same receptor (known as IL28RA) to exert their antiviral, antitumor and immunomodulatory effects. Here, we identified IL28RA genes from the genome of human, chimpanzee, macaque, orangutan, mouse, horse, rat, dog, chicken, and found that only one IL28RA existed in each genome.

GWAS发现大量的银屑病易感基因，其中具有免疫功能的IL28RA基因为中国汉族人银屑病和系统性红斑狼疮的易感基因，也是欧洲人群银屑病的易感基因。 由该基因编码的蛋白质属于II类细胞因子受体家族，位于染色体1p36.11，由9个外显子编码蛋白质。 目前研究较多是IL28RA与IL1... 背景：银屑病是一种较为常见的慢性炎症性皮肤病，以皮肤鳞屑性红斑为主要临床表现，是遗传因素、环境因素和自身免疫共同相互作用结果，其易复发、难治愈，严重影响患者的身心健康。 然 …