
GM-CSF, IL-3, and IL-5 Family of Cytokines: Regulators of ... - PubMed
2019年4月16日 · We discuss preclinical and clinical data, highlighting the potential inherent in targeting these cytokine pathways, the limitations, and the important gaps in understanding of …
GM-CSF, IL-3, and IL-5 Family of Cytokines: Regulators of …
2019年4月16日 · Recently, antibodies targeting IL-5 were approved for the treatment of several allergic or eosinophilic inflammatory diseases including steroid-refractory asthma and an …
白介素家族信号通路及功能概述 - 翌圣生物
各类白介素主要参与肿瘤、自身免疫和炎症等疾病的信号通路,目前机制研究较为透彻的白介素包括il1、il2、il3、il4、il5、il6、il10、il11、il15、il17等,以这些白介素为靶点的上市药物和临 …
自身免疫疾病潜力靶点——IL-5 & IL-5Rα - 知乎 - 知乎专栏
截至目前,全球范围内获批上市的IL-5类药物有三款,其中两款为IL-5抗体:Reslizumab、Mepolizumab;1款为IL-5Rα抗体:Benralizumab。 Mepolizumab是全球首个获批上市的IL-5 …
白细胞介素 3(IL-3) - 丁香通研选
2017年8月31日 · 白细胞介素 3(Interleukin-3,IL-3)又称多集落刺激因子(Multicolony stimulationfactor,Multi-CSF)。 此外,IL-3 还曾被命名为暴式集落促进因子、WHE Ӏ-3 因子 …
研究报告 | 免疫治疗中白介素家族的研发现状 - 健康界
2021年7月30日 · 各类白介素主要参与肿瘤、自身免疫和炎症等疾病的信号通路,目前机制研究较为透彻的白介素包括il1、il2、il3、il4、il5、il6、il10、il11、il 白介素家族介绍
The GM-CSF/IL-3/IL-5 cytokine receptor family: from ligand
Granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and IL-5 are members of a discrete family of cytokines that regulates the growth, differentiation, migration …
Differential Regulation of Human Eosinophil IL-3, IL-5, and GM …
2003年6月1日 · We examined cross-regulation and functional consequences of modulation of eosinophil cytokine receptor expression by IL-3, IL-5 GM-CSF, and eotaxin. Incubation of …
Biology of common beta receptor-signaling cytokines: IL-3, IL
IL-3, IL-5, and GM-CSF are related hematopoietic cytoines that are important for allergic inflammation. The receptors for human IL-5, IL-3, and GM-CSF are members of the …
The IL-3, IL-5, and GM-CSF common receptor beta chain mediates ... - Nature
2021年11月8日 · It is known that IL-3, IL-5, and GM-CSF-dependent STAT5 phosphorylation requires phosphorylation of JAK2 and CSF2RB, the common beta chain of IL-3, IL-5, and GM …