2020年2月17日 · After sensitization with OVA + MC903, the frequency of GATA3 + CD4 + T cells and type 2 cytokine secretion induced by OVA re-stimulation were significantly suppressed in lymphoid cell-specific ...

2024年2月14日 · Previous studies have shown that topical application of MC903, a low-calcemic analog of vitamin D3 (calcipotriol) to mouse skin induces an AD-like dermatitis model recapitulated with features of inflammation, itch, and barrier dysfunction. 36, 37, 38, 39 To explore the role of commensal microbiota in shaping AD-like inflammation, we first ...

MC903-mediated eosinophilia was attenuated in Tnfrsf25 −/− mice , demonstrating a role for TL1A in MC903-driven allergic skin inflammation. Intradermal injection of TL1A into ear skin resulted in a significant increase in the percentage and numbers of eosinophils, but not neutrophils, in Foxp3 eyfp-cre Rora fl/fl mice compared with controls ...

MC903即 卡泊三醇，是一种维生素D3的低钙类似物，广泛用于治疗银屑病。 研究发现，局部使用MC903可激发小鼠上皮角质细胞高表达TSLP，促进CD4+T细胞向Th2细胞分化及激活并释放炎症细胞因子，引起小鼠产生特应性皮炎表型。 数据展示. 图2.使用克立硼罗软膏可明显降低MC903诱导的AD模型组小鼠皮肤厚度及疾病评分，以及细胞因子的水平。 恶唑酮（Oxazolone,OXA）与1,2,4-二硝基氟苯（1,2,4-Dinitrofluorobenzene, DNFB）等化合物属于半抗原，能与皮肤组织蛋 …

2017年2月22日 · We investigated the role of Itln in the pathogenesis of asthma models induced by OVA or house dust mite (HDM), and in AD models induced by vitamin D3 analog calcipotriol (MC903) or HDM.

Here, we uncovered spatial compartmentalization of skin-resident innate lymphoid cells (ILCs) and modulation of sebaceous glands by a subset of RORγt + ILCs residing within hair follicles in close proximity to sebaceous glands.

2022年11月7日 · MC903, applied topically to mouse ears, induces the characteristic signs of AD consisting of swelling, and T H2 type inflammation manifested in a dermal infiltrate. These cardinal criteria for...

ILC2s are enriched in lesional skin of patients with atopic dermatitis and promote MC903-induced atopic inflammation in mice, likely via the production of type 2 cytokines such as interleukin (IL)-5 and IL-13.

目的：：确定肠道菌群代谢产物吲哚－3－甲醛 ( IAID,indole－3－carboxaldehyde)在特应性皮炎 ( AD)小鼠模型中的作用。 方法：将C57小鼠随机分为对照组、模型组和IAID组。 小鼠双耳外涂卡泊三醇 ( MC903)制备AD模型,IAID组给予65μg/kg IAID灌胃,模型组灌等体积DMSO作为对照,对照组不处理。 10天后肉眼观察大体炎症情况,千分尺测量小鼠耳廓厚度,ELISA法检测小鼠血清中总IgE水平并通过RT－PCR的方法检测全皮中IL4,IL5,IL6,IL13,IL33,TSLP的表达。

In this study, we employed the murine model of MC903-induced AD-like disease to recapitulate human AD. MC903-treated mice were previously reported to exhibit enhanced susceptibility to respiratory atopy in models of allergic airway disease in addition to developing a chronic eczematous dermatitis associated with xerosis . In conjunction with ...