In humans, it is encoded by the IL6 gene. [5] In addition, osteoblasts secrete IL-6 to stimulate osteoclast formation. Smooth muscle cells in the tunica media of many blood vessels also produce IL-6 as a pro-inflammatory cytokine.

HIV-1 Tat induces the expression of the interleukin-6 (IL6) gene by binding to the IL6 leader RNA and by interacting with CAAT enhancer-binding protein β (NF-IL6) transcription factors. J Biol Chem 272: 14883–14892 [ DOI ] [ PubMed ] [ Google Scholar ]

Dec 25, 2024 · IL6 is a potent inducer of the acute phase response. Rapid production of IL6 contributes to host defense during infection and tissue injury, but excessive IL6 synthesis is involved in disease pathology.

Interleukin-6 (IL-6) is a member of the pro-inflammatory cytokine family, induces the expression of a variety of proteins responsible for acute inflammation, and plays an important role in the proliferation and differentiation of cells in humans. IL-6 signaling is mediated by building a …

Mar 29, 2021 · Image Credit: StudioMoleKuul / Shutterstock.com IL-6 and inflammation. Besides being an immune protein, IL-6 is also a pyrogen and is responsible for fever in autoimmune, infectious, or non ...

IL-6 is implicated in the development and progression of autoimmune diseases in part by influencing CD4 T cell lineage and regulation. Elevated IL-6 levels drive inflammation in a wide range of autoimmune diseases, some of which are also ...

Biochemically, interleukin-6 belongs to the class of four-helical cytokines. The cytokine can be synthesised and secreted by many cells. It acts via a cell surface-expressed interleukin-6 receptor, which is not signalling competent. This receptor, ...

May 17, 2021 · Thériault S, Dina C, Messika-Zeitoun D, Le Scouarnec S, Capoulade R, Gaudreault N, Rigade S, Li Z, Simonet F, Lamontagne M, et al; D.E.S.I.R. Study Group. Genetic association analyses highlight IL6, ALPL, and NAV1 As 3 new susceptibility genes underlying calcific aortic valve stenosis.

Apr 21, 2015 · Almost all stromal cells and cells of the immune system produce IL-6, and while IL-1β and tumor-necrosis factor are major activators of IL6 expression, other pathways such as Toll-like...

Sep 4, 2014 · Interleukin 6 (IL-6), promptly and transiently produced in response to infections and tissue injuries, contributes to host defense through the stimulation of acute phase responses, hematopoiesis, and immune reactions. Although its expression is strictly controlled by transcriptional and posttranscri …